... bacterial and viral meningitis were reliably excluded. Results: We identified seven studies investigating 270 term and 96 preterm neonates. There were minimal differences between preterm and term neonates in the CSF white blood cell (WBC) count and glucose concentration. In contrast, the CSF neutrophil...

... of inflammatory proteins in neonatal neutrophils. Methods: Neutrophils were isolated from umbilical cord blood, and from adults for comparison, and treated with bilirubin (10–300 µmol/l, equivalent to unbound bilirubin 3–40 nmol/l), in the presence or absence of lipopolysaccharide (LPS). Expression of genes...

...C. Lothian; C. Dahlgren; H. Lagercrantz; J. Lundahl We investigated the expression and the N-formyl-methionyl-phenylalanine (fMLP)- and interleukin-8 (IL-8)-induced mobilisation of the complement regulatory proteins CR1 (CD 35), decay-accelerating factor (CD55) and CD59 on neutrophils in neonates...

...A.E. Falconer; R. Carr; S.W. Edwards Preterm neonates are vulnerable to infection as a result of a compromised immune system. The function of neutrophils from ‘well’, ‘stressed’, and ‘maturing’ preterm neonates was compared with term neonate and adult neutrophils using a whole-blood phagocytosis...

...Hasan Özkan; Nurullah Akkoç; Adem Aydın; Salih Kavukçu; Nur Olgun; Gülersu Irken; Faize Akyol; Necla T. Çevik In this study, using flow cytometry, we investigated the autofluorescence emitted by lymphocytes, monocytes and neutrophils exposed to different unconjugated bilirubin concentrations...

... distributed into the lung and that pulmonary bacterial uptake exhibited a close temporal relationship with the onset of pulmonary hypertension. Companion studies demonstrated that the extent of pulmonary 111 In-neutrophil sequestration was unaffected by GBS, although a neutrophil secretagogue, phorbol...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cord blood Flow cytometry Neutrophils Biol Neonate 1989;55:156-163 Fc and Complement Receptor (CR1 and CR3) Expression...

...Herbert A. Lassiter; Robert D. Christensen; Charles Parker; Gerald Rothstein Neonates are particularly susceptible to infection with Escherichia coli K1. To investigate the mechanisms which lead to this susceptibility, we examined: (a) the bactericidal activity of neutrophils; (b) opsonization...

... and neutrophils..In addition, two types of what have been termed ‘lymphocytoid’ phagocytes were seen. These resemble lymphocytes in their morphology. One type possesses basophilic cytoplasm, and has been found only in premature cord blood. The presence of lymphocytoid phagocytes affords a further indication...

... polymorphonuclear neutrophils following exposure to hyperoxia and NO in vitro. Methods: Neonatal cord blood was exposed to room air, 25, 30 and 100% oxygen and 10 or 20 ppm NO added to the different oxygen concentrations for up to 30 min. 4,5-Diaminofluorescein diacetate (DAF-2 DA) is an intracellular dye used...

... was comparable in the 2 groups. The lung tissue ultrastructural and histological changes, number of apoptotic cells and phospholipase A 2 activity were similar in the 2 groups. The amount of neutrophil accumulation, assessed by myeloperoxidase activity, was however significantly increased in macroscopically...

... for each group). While pups treated with dexamethasone showed greatly improved survival compared to O 2 controls, there was no decrease in neutrophil influx into the lung as measured by lung myeloperoxidase and neutrophil counts in histologic specimens and lavage fluid. Catalase, glutathione peroxidase...

...Magdy Ahmad; Howard B. Fleit; Marc G. Golightly; Edmund F. La Gamma Neutrophil dysfunction may contribute to an increased risk of sepsis in very-low-birth-weight (VLBW) neonates. The current study was designed to determine whether recombinant human granulocyte colony-stimulating factor (rhG-CSF...

...Peter Gessler; Clemens Dahinden To study neutrophil activation in cord blood as a function of the mode of delivery, we performed analysis of the function of neutrophil granulocytes by assessing their ability to produce reactive oxygen products (ROP) as well as neutrophil cell surface expression...

... mediating neutrophil functions, including respiratory burst, chemotaxis, and motility. We hypothesize that theophylline causes reduced respiratory burst activity, chemotaxis, and random motility in neutrophils. In these studies, we aim at determining the effects of theophylline on neutrophil function...

...Peter Gessler; Stefan Neu; Yvonne Brockmann; Christian P. Speer Granulocyte colony-stimulating factor (G-CSF) promotes neutrophil production and enhances neutrophil function. The effects of G-CSF are mediated by binding to its receptor. Since neutrophils are an essential part of the neonatal host...

...-related stress. Mean leukocyte and neutrophil counts were higher in infants born by vaginal delivery in cord blood and up to 12 h of life. No significant differences were observed in the immature: total neutrophil ratios between the two groups of infants. The cord serum cortisol level was higher...