... and hypothesized that nicotine infusion in a newborn piglet model of asphyxia would decrease the immune response and be neuroprotective. Methods: Newborn piglets ( n = 41) were randomized to one of three groups after hypoxia: two groups receiving nicotine, (1) 18 µg/kg/h ( n = 17), (2) 46 µg/kg/h ( n = 15), and (3...

..., and the combination increased the numbers of viable neurons to 1.4 × 10 6 /putamen, 1.4 × 10 6 /putamen, and 2.1 × 10 6 /putamen, respectively. Notably, the combined treatment improved neuroprotection compared to individual therapy. Conclusion: We conclude that simultaneous inhibition of dopamine D1 receptors...

... for fetal neuroprotection in our neonatal intensive care unit. This study aimed to test whether antenatal MgSO 4 use was associated with increased risk of MRI in EPIs. Methods: The incidences of complicated MRI requiring aggressive enema or surgical intervention and other intestinal complications were...

... therapies, such as melatonin, are needed to provide additional neuroprotection. Objectives: The aim of this study was to determine a range of melatonin concentrations that could result in neuroprotective synergy with hypothermia. Methods: Hypoxia-ischemia was simulated by transient oxygen-glucose...

... in survivors. Therapeutic hypothermia, while beneficial, still leaves many treated infants with lifelong disabilities. Adjunctive therapies are needed, and erythropoietin (Epo) has the potential to provide additional neuroprotection. Objectives: The aim of this study was to review the current incidence...

...Mari Falck; Damjan Osredkar; Thomas Ragnar Wood; Elke Maes; Torun Flatebø; Hemmen Sabir; Marianne Thoresen Background: After neonatal asphyxia, therapeutic hypothermia (HT) is the only proven treatment option. Although established as a neuroprotective therapy, benefit from HT has been questioned...

...Håvard T. Garberg; Rønnaug Solberg; Jon Barlinn; Jose Martinez-Orgado; Else-Marit Løberg; Ola Didrik Saugstad Background: Cannabidiol (CBD) is considered a promising neuroprotectant after perinatal hypoxia-ischemia (HI). We have previously studied the effects of CBD 1 mg/kg in the early phase after...

... in neurological impairment in the absence of treatments specifically aimed at neuroprotection. Objectives: We examined whether recent changes in treatment strategies in perinatal care during the perinatal period could have had an indirect beneficial impact on the occurrence of brain lesions and their consequences...

.... Hypothermia Newborn Time Outcome Neuroprotection Therapeutic hypothermia (HT) has become the standard treatment for newborns suffering neonatal encephalopathy after perinatal asphyxia [ 1 ]. Meta-analysis of the randomized controlled cooling trials (RCTs) has shown that HT significantly improves...

... revealed modest neuroprotection afforded by H 2 . Conclusions: Severe stimulus-selective delayed neurovascular dysfunction develops and persists even after mild H/I stress. H 2 alleviates this delayed neurovascular dysfunction that can contribute to its neuroprotective effect. 26 11 2012 28 01...

... Perinatal asphyxia Neurodevelopment Neuroprotection Introduction Table 2 Outcome of hypothermia in the Netherlands and Flanders compared to data of large randomized trials of therapeutic hypothermia in asphyxiated full-term neonates Of the 308 patients without congenital malformations, 42...

...Christof Dame; Juliane Langer; Brigitte M. Koller; Jean-Claude Fauchère; Hans Ulrich Bucher Background: High-dose recombinant human erythropoietin (rEpo) has first been administered in clinical trials for neuroprotection in very preterm neonates at high risk of brain injury and in (near-) term...

...Merih Cetinkaya; Tülin Alkan; Fadil Ozyener; Ilker Mustafa Kafa; Mustafa Ayberk Kurt; Nilgun Koksal Background: Perinatal hypoxia-ischemia is a major cause of mortality and long-term neurological deficits. Objectives: The objective of this study was to compare the effects of two neuroprotective...

... shown that this drug prevents or significantly reduces the extent of cortical neurone infarction following experimental asphyxia in 7-day-old rat pups. Unfortunately, MK-801 is toxic to the pup, but newer NMDA receptor antagonists may offer the opportunity for neuroprotection in the human infant who has...

... and clinical studies demonstrate that EPO has neuroprotective effects related to its anti-apoptotic and vascular growth-promoting properties. Although under basal conditions the fetal kidneys are the main site of EPO production, during hypoxia recent experimental data indicate an important role of the placenta...

...Angela S. Geiger; Ann C. Rice; Steven M. Shapiro Background: Extreme hyperbilirubinemia is treated with double volume exchange transfusion, which may take hours to commence. A neuroprotective agent that could be administered immediately might be clinically useful. Minocycline, an anti-inflammatory...

...Saraid S. Billiards; Phuong N. Nguyen; Jean-Pierre Scheerlinck; David J. Phillips; Benedict J. Canny; David W. Walker; Jonathan J. Hirst Background: Allopregnanolone is a neurosteroid produced in the brain that can alter the excitability of the CNS. Neurosteroids have neuroprotective properties...

...Ronald J. McPherson; Eric J. Demers; Sandra E. Juul Background: High-dose recombinant erythropoietin (rEpo) is neuroprotective in neonatal animal models of brain injury, but the long-term consequences of neonatal exposure have not been studied. Objectives: We hypothesized that multiple injections...

... that systemic dosing of high-dose recombinant Epo (rEpo) would result in neuroprotective rEpo concentrations in the spinal fluid of adult and developing animals. This report characterizes the pharmacokinetics of high-dose rEpo in the blood and spinal fluid of juvenile and adult nonhuman primates (n = 7...

... suggest a different role of Epo in normal brain development than in neuroprotection and neuronal tissue repair after brain injury. Epo concentrations in the cerebrospinal fluid may have primary paracrine effects. While the transport of Epo across the intact blood brain barrier (BBB) is generally limited...