...Saima Aslam; Mary O'Dea; Lynne A. Kelly; Amanda O'Neill; Ellen McKenna; Tim Hurley; Aoife Branagan; David O'Driscoll; Caoimhe Normile; Shahid Saleemi; Deirdre Sweetman; Claudine Vavasseur; John Murphy; Veronica Donoghue; William Watson; Eleanor J. Molloy Introduction: Melatonin has...

... therapies, such as melatonin, are needed to provide additional neuroprotection. Objectives: The aim of this study was to determine a range of melatonin concentrations that could result in neuroprotective synergy with hypothermia. Methods: Hypoxia-ischemia was simulated by transient oxygen-glucose...

... agents; magnesium sulfate and melatonin, administered alone or in combination, on brain infarct volume and TUNEL positivity in a neonatal hypoxic-ischemic (HI) rat model. Methods: After being anesthetized, 7-day-old pups (n = 80) underwent ischemia followed by exposure to hypoxia for 2 h. The pups were...

...Fumiaki Hamada; Kazushi Watanabe; Akihiko Wakatsuki; Ryuhei Nagai; Koichi Shinohara; Yoshihiro Hayashi; Rina Imamura; Takao Fukaya Background: We have previously demonstrated that prophylactic administration of melatonin to pregnant rats can protect against ischemia/reperfusion (I/R)-induced...

...A. Muñoz-Hoyos; A. Bonillo-Perales; R. Ávila-Villegas; M. González-Ripoll; J. Uberos; J. Florido-Navío; A. Molina-Carballo Aim: Melatonin is a potent free radical scavenger and an indirect antioxidant. Knowledge about the behavior of melatonin secretion in the early neonatal period, which may...