... therapies, such as melatonin, are needed to provide additional neuroprotection. Objectives: The aim of this study was to determine a range of melatonin concentrations that could result in neuroprotective synergy with hypothermia. Methods: Hypoxia-ischemia was simulated by transient oxygen-glucose...

...F. Carratalá; M. Moya; E. Ferrer We studied the effects of mild/moderate hypoxia-ischemia in 90 newborn Wistar rats divided into 3 groups. Two of the three groups were submitted to two different levels of hypoxia (FiO 2 = 0.05, group F5 and FiO 2 = 0.1, group F10) and the third to normoxia (FiO 2...

...Mamoru Tanaka; Michiya Natori; Hitoshi Ishimoto; Kei Miyakoshi; Toyohiko Miyazaki; Toshifumi Kobayashi; Yasunori Yoshimura We investigated the effects of thromboxane (TX) A 2 in rats with ischemia-reperfusion-induced intrauterine growth retardation. A saline solution or OKY-046, a selective TXA 2...

... without hypoxia or ischemia. Brain ATP was 1.7 ± 0.09 μmol/g wet weight in the shams, 0.98 ± 0.09 in the glucose group (p < 0.01 vs. sham), and 0.52 ± 0.10 in the insulin group (p < 0.01 vs. glucose). Brain lactate levels were 4.3 ± 1.0 μmol/g wet weight in the shams, 18.3 ± 1.9 in the insulin group...

...S.A. Anderson; L.J. Carr; T.D. Schierling; G.J. Kost Phosphorus-31 nuclear magnetic resonance and left ventricular pressure development (dP/dt) were used to test the hypothesis that age-related differences in myocardial functional recovery after ischemia and cold crystalloid cardioplegia (CCC...

...% of rat pups subjected to hypoxia-ischemia with a 27.8 ± 1.2% weight deficit of the damaged hemisphere. MK-801 in doses of 0.3 and 0.5 mg/kg i.p. reduced the brain damage by 61% (p < 0.001) and 43% (p < 0.001), respectively. A higher dose of MK-801 (0.75 mg/kg) did not offer neuroprotection...

... differences in the degree of damage between the two groups. 25 9 2009 Fructose-1,6-diphosphate Hypoxia Ischemia Brain, newborn pig © 1991 S. Karger AG, Basel 1991 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

... heart Neonatal and adult hearts Ischemia Reperfusion Superoxide dismutase Catalase Glutathione peroxidase Heart Biol. Neonate 51: 156-169 (1987) Age-Related Development Profiles of the Antioxidative Defense System and the Peroxidative Status of the Pig Heart Dipak K. Das, Donna Flansaas...

...J.H. Fischer; W. Isselhard The metabolic states of various tissues of newborn rabbits were studied before and after periods of ischemia of 5–40 min. The contents of substances of the energy distributing adenylic acid-creatine phosphate system as well as glycogen, glucose and lactate were determined...

... of age due to weak femoral pulses noted on the routine nursery discharge examination. The cardiac examination revealed weak pulses everywhere and mild tachypnea and tachycardia. An electrocardiogram showed clear signs of ischemia. Echocardiography demonstrated an anomalous origin of the left coronary...

...Matthias Seehase; Thomas Quentin; Elke Wiludda; Gerhard Hellige; Thomas Paul; Holger Schiffmann Background: Neonatal hearts are less susceptible to developing myocardial dysfunction after hypoxia and/or ischemia than adult hearts. Differences in intracellular calcium homeostasis may be responsible...

...Ihsan Solaroglu; Ozerk Okutan; Ayse Solaroglu; Erkan Kaptanoglu; Etem Beskonakli; Kamer Kilinc The purpose of this study was to investigate whether propofol has a neuroprotective effect on the fetal brain after intrauterine ischemia-reperfusion (I/R) injury in the rat fetus. Fetal brain ischemia...

...Abdullah Kumral; Huseyin Baskin; Necati Gokmen; Osman Yilmaz; Kursad Genc; Sermin Genc; M. Mansur Tatli; Nuray Duman; Erdener Ozer; Hasan Ozkan Erythropoietin (Epo) exerts neuroprotection against neuronal death induced by ischemia and hypoxia in vitro and in vivo. Recent studies suggest...

...Abdullah Kumral; Erdener Ozer; Osman Yilmaz; Mustafa Akhisaroglu; Necati Gokmen; Nuray Duman; Cagnur Ulukus; Sermin Genc; Hasan Ozkan Erythropoietin (Epo) prevents ischemia and hypoxia-induced neuronal death in vitro. Recent studies have shown that this cytokine also has in vivo neuroprotective...

.... Erythropoietin Erythropoietin receptor Erythropoietin mimetic peptide Neurodevelopment Neuroprotection Asphyxia Intraventricular hemorrhage Ischemia Stroke Biol Neonate 2001;79:228 235 The Biology of Erythropoietin in the Central Nervous System and Its Neurotrophic and Neuroprotective Potential...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Caspase Neonatal rat Brain Hypoxia Ischemia Apoptosis Poly(ADP-ribose) polymerase Inhibitor of caspase-activated...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Birth asphyxia Somatosensory evoked potentials Hypoxia Ischemia Oxygen free radicals Original Paper Biol Neonate...

..., instructions or products referred to in the content or advertisements. Brain Flunarizine Ginkgo biloba Ischemia Perinatal asphyxia Platelet-activating factor Original Paper Biol Neonate 1998;74:439 444 Mete Akisüa Nilgün Kültürsaya Isil Cokerb Afig Hüseyinova a Department of Pediatrics, Ege...

...-Fraction, Troponin-T, QT-Intervals) and Serum Creatinine for the Retrospective Diagnosis of Perinatal Asphyxia OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO Key Words Troponin T Asphyxia Creatinine kinase Creatinine Ischemia Hypoxia OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO...