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Keywords: Indomethacin
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Journal: Neonatology
Neonatology (2011) 101 (1): 20–27.
Published Online: 26 July 2011
...Arvind Sehgal; C. Andrew Ramsden; Patrick J. McNamara Background: A haemodynamically significant ductus arteriosus (HSDA) is commonly associated with morbidity in preterm infants. Aim: To study the effect of the first dose of indomethacin on coronary blood flow in preterm neonates diagnosed...
Journal Articles
Journal Articles
Journal Articles
Journal: Neonatology
Biology of the Neonate (1994) 66 (6): 359–366.
Published Online: 30 September 2009
...P.T. Louis; Y. Yamashita; J. Del Toro; L.H. Michael; C.F. Contant; J. Goddard-Finegold Indomethacin has been shown to reduce cerebral blood flow and cerebral blood flow velocities in newborn infants and animals of various species. To answer the question of whether there may be a compromise...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1994) 66 (6): 367–375.
Published Online: 30 September 2009
...Jane E. McGowan; Joseph C. McGowan III; Om P. Mishra; M. Delivoria-Papadopoulos To test the hypothesis that indomethacin, an inhibitor of cyclooxygenase, reduces free radical-induced brain cell membrane changes during cerebral hypoxia, we determined levels of brain cell membrane lipid peroxidation...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1995) 68 (5): 342–353.
Published Online: 30 September 2009
... sepsis. In order to characterize the cardiopulmonary responses to TNF in a young animal model and to determine to what extent these changes were secondary to cyclooxygenase byproducts, three groups of mechanically ventilated piglets received an infusion of either TNF, indomethacin followed by TNF (Indo...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1992) 61 (3): 142–149.
Published Online: 30 September 2009
...Viola Prietsch; Rolf Maier; Lothar Schmitz; Michael Obladen Long-term variability (LTV) of heart rate was calculated continuously by a microprocessor in 25 preterm infants undergoing indomethacin treatment for closure of patent ductus arteriosus (PDA), in 24 preterm infants without signs of PDA...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1991) 60 (5): 273–282.
Published Online: 25 September 2009
... receiving prophylactic indomethacin, 0.2 mg/kg, i.v. 24 h after birth. Infants who developed symptomatic PDA were more likely to be white and male and have more severe pulmonary insufficiency than infants who did not develop symptomatic PDA. Serum indomethacin levels were similar in both groups of patients...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1988) 54 (5): 254–262.
Published Online: 25 September 2009
...N. Laudignon; S. Chemtob; H. Bard; J.V. Aranda Using the Doppler technique, the effect of therapeutic doses of indomethacin on the cerebral blood flow velocity (CBFV) of anterior cerebral arteries was studied in 13 preterm infants with patent ductus arteriosus. The first intravenous injection...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1986) 50 (4): 177–181.
Published Online: 24 September 2009
...J.-B. Gouyon; J.-P. Guignard Oliguria in the neonate usually reflects a fall in glomerular filtration rate (GFR) secondary to prerenal disturbances such as hypovolemia, hypotension, hypoxemia and cardiac failure, or to vasoactive drugs such as indomethacin and tolazoline. The action of such drugs...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1986) 50 (2): 83–90.
Published Online: 24 September 2009
...Martine Clozel; Kae Beharry; Jacob V. Aranda Indomethacin is now widely used during the neonatal period, but few data exist concerning its metabolism during this period. Thus, we studied the maturational changes in the metabolism of indomethacin into desmethylindomethacin by isolated liver...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1986) 50 (5): 270–273.
Published Online: 24 September 2009
...M.O. Pulkkinen; K. Momma; J. Pulkkinen Progesterone substitution in the rat during pregnancy days 17–21 or administration 6 h before spontaneous delivery constricted the fetal ductus arteriosus. The rapid whole-body freezing technique was used. Indomethacin-induced constriction of the fetal ductus...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1987) 51 (5): 249–254.
Published Online: 24 September 2009
... by pretreatment with M-AVP, the pups were able to raise their body temperature to febrile levels. The antipyretic drug, indomethacin, prevented these fevers. We conclude that endogenous AVP is a physiologically important antipyretic substance in the brain of the newborn rat. 24 9 2009 Biol. Neonate 51...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1987) 51 (4): 212–216.
Published Online: 24 September 2009
... resistance were lower in newborn tubules. The sodium flux into the lumen was unaffected by indomethacin. These observations suggest that the newborn collecting tubule may be unable to maintain an adequate sodium gradient for the optimal function of the urinary concentrating mechanism, and that endogenous...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1988) 53 (4): 243–252.
Published Online: 24 September 2009
..., an alpha-adrenergic blocking agent useful in the treatment of persistent pulmonary hypertension of the neonate induces intense renal vasoconstriction with consequent hypoperfusion. Indomethacin, a prostaglandin synthetase inhibitor used for the pharmacological closure of a patent ductus arteriosus, also...
Journal Articles
Journal: Neonatology
Biology of the Neonate (1985) 47 (5): 265–269.
Published Online: 18 September 2009
...Marie J. Stuart; Jon Dusse Neonates manifest more hemorrhagic tendencies when exposed to either acetylsalicyclic acid (ASA) or indomethacin in comparison to adults. We therefore assessed the susceptibility of neonatal and adult platelets to the effects of these cyclooxygenase inhibitors in vitro...