... . 4. Thornton   C , Leaw   B , Mallard   C , Nair   S , Jinnai   M , Hagberg   H . Cell death in the developing brain after hypoxia-ischemia . Front Cell Neurosci . 2017 ; 11 : 248 . 10.3389/fncel.2017.00248 . 5. Douglas-Escobar   M , Weiss   MD . Hypoxic...

... of NLRP3 or ASC protects against neonatal HI brain damage 7 days after hypoxia-ischemia. Methods: C57BL/6J, NLRP3 –/– , and ASC –/– mice were subjected to unilateral common carotid artery ligation followed by hypoxia at P9. Brain infarction, apoptosis, and microglial response were evaluated, as well...

... the neuroprotective role of Xe in a lipopolysaccharide (LPS)- and hypoxia-ischemia (HI)-induced white matter damage (WMD) model. Methods: Three-day-old Sprague-Dawley rats were randomly divided into a sham group (group A, n = 24), an LPS + HI group (group B, n = 24), and an LPS + HI + Xe group (group C, n = 72...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hypoxia-ischemia Neonatal encephalopathy...

... infarction was evaluated by histopathology and 2,3,5-triphenyltetrazolium chloride staining. Plasma levels of IL-18 were measured by ELISA. Double labeling immunohistochemistry was used to examine cell-specific NLRP3 expression. Results: NLRP3 was upregulated 24 h after hypoxia-ischemia (HI...

... effects against brain injury. Objectives: Our aim was to evaluate the levels of angiogenesis-related cells (CD34+ cells) and angiogenic factors (vascular endothelial growth factor, VEGF, and angiopoietin-1, Ang-1) in a neonatal rat model of cerebral unilateral hypoxia-ischemia (HI) and to identify...

...Marius Widerøe; Christian Brekken; Annemieke Kavelaars; Tina Bugge Pedersen; Pål Erik Goa; Cobi Heijnen; Jon Skranes; Ann-Mari Brubakk Background: Hypoxia-ischemia (HI) in the neonatal brain results in a prolonged injury process. Longitudinal studies using noninvasive methods can help elucidate...

...Merih Cetinkaya; Tülin Alkan; Fadil Ozyener; Ilker Mustafa Kafa; Mustafa Ayberk Kurt; Nilgun Koksal Background: Perinatal hypoxia-ischemia is a major cause of mortality and long-term neurological deficits. Objectives: The objective of this study was to compare the effects of two neuroprotective...

...Lauren L. Jantzie; Po-Yin Cheung; Scott T. Johnson; David L. Bigam; Kathryn G. Todd Background: Neonatal hypoxia-ischemia (HI) is a common clinical occurrence. Recently, much evidence has been gathered to suggest that oxygen free radicals are implicated in the pathogenesis of hypoxia-reoxygenation...

...Robert C. Vannucci; Anthony Rossini; Javad Towfighi; Susan J. Vannucci To ascertain the manner in which the severity of perinatal brain damage occurs as a result of hypoxia-ischemia, 7-day postnatal rats were subjected to unilateral common carotid artery ligation followed thereafter by exposure...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nitric oxide synthase inhibition Hypoxia-ischemia N ω -Nitro- L -arginine Pulmonary artery pressure Oxygen need Brain damage Biology o f the Neonate Original Paper...

...Robert C. Vannucci; Dennis J. Mujsce Investigations suggest that hyperglycemia superimposed on hypoxia-ischemia or cerebral ischemia accentuates brain damage in adult experimental animals and humans. Such does not appear to be the case in immature animals. The present review discusses fundamental...

...-dose dexamethasone (4 mg/kg) or high-dose dexamethasone (40 mg/kg). Neither low-dose nor high-dose dexamethasone ameliorated the brain edema, lactacidemia, or hypoglycemia associated with hypoxia-ischemia. In addition, dexamethasone did not alter the pattern of neuropathologic damage or reduce the fall...

...Mathias Karlsson; Saulius Satas; Janet Stone; Helen Porter; Marianne Thoresen Background: The term newborn pig is an established model for studying both brain and organ pathology after hypoxia-ischemia (HI). Serial liver enzyme activity is often used to predict liver injury but little is known...

... Departments of aNeonatology and bPathology, University Medical Center Utrecht, Utrecht, and Departments of cPediatric Neurology and dPsychiatry and Neuropsychology, University Hospital, Maastricht, The Netherlands Key Words Neonates, spinal cord changes Spinal cord Hypoxia-ischemia Nitric oxide...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Superoxide dismutase Glutathione Malondialdehyde Hypoxia-ischemia Brain Rat Newborn Growth hormone Original Paper Biol Neonate 2006;90:168 173 DOI: 10.1159...

... oxide Hypoxia-ischemia Brain damage Original Paper Biol Neonate 2005;88:291 298 DOI: 10.1159/000087626 Received: July 22, 2004 Accepted after revision: January 24, 2005 Published online: August 18, 2005 Neuroprotective Effect of L-Arginine in a Newborn Rat Model of Acute Severe Asphyxia J. Martínez...

... artery ligation followed by hypoxic exposure with 8% O 2 for 2 h) was performed on 7-day-old rats. After hypoxia-ischemia the rats were reoxygenated with either 100% O 2 (hyperoxia group) or 21% O 2 (room air group) for 24 h and then returned to the dam. The rats were killed 1 week after the experiment...

...Kristin Lyng; Berit H. Munkeby; Ola Didrik Saugstad; Babill Stray-Pedersen; J. Frederik Frøen Objective: Previous animal studies indicated that interleukin (IL)-10 attenuates the inflammatory response to a challenge by inflammation and hypoxia-ischemia, but the effect of IL-10 administration after...

...Hirotsugu Fukuda; Takuji Tomimatsu; Takeshi Kanagawa; Junwu Mu; Masatomo Kohzuki; Koichiro Shimoya; Takayoshi Hosono; Toru Kanzaki; Yuji Murata The effects of postischemic hyperthermia were investigated in the newborn rat brain after hypoxia-ischemia (HI). Seven-day-old rats were subjected to left...