...Enrico Cocchi; Juleda Shabani; Arianna Aceti; Gina Ancora; Luigi Corvaglia; Federico Marchetti Introduction: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal mortality and neurodevelopmental disabilities. Therapeutic hypothermia (TH) is the standard of care, but optimized...

... outcomes in a multicenter cohort of newborn infants with hypoxic-ischemic encephalopathy (HIE) that underwent therapeutic hypothermia. We hypothesized that subjects with acute placental abnormalities would have reduced risk of death or neurodevelopmental impairment (NDI) at 2 years of age after undergoing...

...-ischemic encephalopathy (HIE) during the last decade of therapeutic hypothermia (TH). Methods: Multicenter cross-sectional study of all infants ≥35 weeks gestational age diagnosed with moderate-to-severe HIE within 6 h of birth in an extensive region of Spain between 2011 and 2019, in order to detect trend...

... to in the content or advertisements. Despite many efforts to minimize the heat loss, hypothermia continues to be an important problem in preterm infants. In attempts to generate heat and compensate for hypothermia, a preterm infant can experience hypoxia, hypoglycemia, metabolic acidosis, or solute excretion...

...Poorva Deshpande; Amish Jain; Patrick J. McNamara Background: Phenobarbitone induces suppression of cerebral electrical activity on amplitude-integrated electroencephalography (aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE); however, its effect during therapeutic hypothermia (TH) has...

...Silvia Carloni; Fabrizio Facchinetti; Nicola Pelizzi; Giuseppe Buonocore; Walter Balduini Background: Hypoxic-ischemic encephalopathy is a major cause of neonatal morbidity. Therapeutic hypothermia, while beneficial, still leaves many treated infants with lifelong disabilities. Thus, adjunctive...

...Marc R. Mendler; Ines Mendler; Mohammad A. Hassan; Benjamin Mayer; Harald Bode; Helmut D. Hummler Background: The so-called Thompson-score (TS) for newborns with hypoxic-ischemic encephalopathy (HIE) was developed before the introduction of controlled hypothermia as clinical routine. Information...

.... Objective: To investigate the neuroprotective effects of hypothermia on bilirubin-induced toxicity in primary mouse neuronal cell cultures. Methods: Hippocampal cell cultures, isolated from newborn mouse brains, were incubated with unconjugated bilirubin (UCB) at 3 days in vitro (DIV) and immediately...

... feedings during hypothermia lacks supporting evidence. Objectives: We aimed to determine if minimal enteral nutrition (MEN) during hypothermia in patients with hypoxic-ischemic encephalopathy was associated with a reduced duration of parenteral nutrition, time to full oral feeds, and length of stay...

...Panagiotis Kratimenos; Ioannis Koutroulis; Amit Jain; Shadi Malaeb; Maria Delivoria-Papadopoulos Background: Hypoxia-ischemia (HI) results in increased activation of Ca 2+ /calmodulin kinase IV (CaM kinase IV) mediated by Src kinase. Therapeutic hypothermia ameliorates neuronal injury...

...Siv Fredly; Cathrine S. Nygaard; Janne H. Skranes; Tom Stiris; Drude Fugelseth Background: Therapeutic hypothermia is presumed to suppress inflammatory processes after perinatal asphyxia. In a previous study of neonatal hypoxic-ischemic encephalopathy (HIE) we found altered skin microcirculation...

...Haiqing Leng; Haiyan Wang; Biyun Lin; Guoqiang Cheng; Laishuan Wang Background: Transitional hypothermia (TH) is associated with increased morbidity and mortality in very low birth weight (VLBW) infants worldwide. Objectives: To assess the effect of a quality improvement project (QIP) on outborn TH...

...Dulip Jayasinghe The focus of this review is to collate the literature on the phenomenon of impaired thermal adaptation after hypoxic ischaemic (HI) delivery often culminating in hypothermia. This phenomenon appears different in severity and duration to a spontaneous postnatal fall in temperature...

...Marcel P.H. van den Broek; Henrica L.M. van Straaten; Alwin D.R. Huitema; Toine Egberts; Mona C. Toet; Linda S. de Vries; Karin Rademaker; Floris Groenendaal Background: Midazolam is used as an anticonvulsant in neonatology, including newborns with perinatal asphyxia treated with hypothermia...

... (RI) ≤0.55 was predictive of poor outcome in normothermic NE infants. Recent studies have questioned its predictive power during therapeutic hypothermia (HT). Objective: To assess the predictive power of RI during HT and after rewarming. Methods: 45 infants with NE treated with HT for 72 h had...

...Marianne Thoresen; James Tooley; Xun Liu; Sally Jary; Peter Fleming; Karen Luyt; Anoopam Jain; Pamela Cairns; David Harding; Hemmen Sabir Objective: Therapeutic hypothermia (HT) is the standard treatment for newborns after perinatal asphyxia. Preclinical studies report that HT is more effective...

.... Objective: To determine if DHA administration in addition to hypothermia, now standard care for neonatal asphyxial brain injury, attenuates post-HI damage and sensorimotor deficits. Methods: Seven-day-old (P7) rats underwent right carotid ligation followed by 90 min of 8% O 2 exposure. Fifteen minutes later...

... Group on Neonatal Neurology Background: Therapeutic hypothermia was introduced in the Netherlands and Flanders, Belgium, in 2008. Since then, an increasing number of patients has been treated - up to 166 in 2010. Complications and outcome were registered in an online database. Objectives: The aim...

...Gerburg Keilhoff; Uwe Ebmeyer; Lorenz Schild Vijlbrief et al. [Neonatology 2012;102:243–248] reported a beneficial effect of hypothermia on cardiac function after perinatal asphyxia indicated by low levels of B-type natriuretic peptide (BNP). Elevated troponin I plasma levels, however, reflects...

...D.C. Vijlbrief; M.J.N.L. Benders; H. Kemperman; F. van Bel; W.B. de Vries Background: Little is known about the effects of hypothermia on the cardiovascular system in term newborns with neonatal encephalopathy. Objectives: To evaluate whether mild hypothermia for neonatal encephalopathy...