... challenge for physicians. There are no consensus and systematic review on the use of fentanyl, the most commonly used pain reliever in preterm neonates during mechanical ventilation. We aim to compare the benefits and harms of fentanyl versus placebo or no drug for preterm neonates receiving mechanical...

...Souvik Mitra; M. Ege Babadagli; Tara Hatfield; Averie dePalma; Helen McCord; Walid El-Naggar; Georg M. Schmölzer; Douglas D. McMillan Background: Fentanyl is a commonly used off-label medication for pain control and sedation in preterm infants. Yet, the effect of fentanyl on cerebral hemodynamics...

...M. Giroux; M.G. Teixera; J.C. Dumas; R. Desprats; H. Grandjean; G. Houin The placental transfer of three opioids used in peridural analgesia, fentanyl, alfentanil and sufentanil, and two reference substances, antipyrine and *H 2 O, was determined ex vivo in the human placental cotyledon system. (1...

...Vigna Rajan; Kay D.A. Beharry; Paul Williams; Houchang D. Modanlou The objective of this study was to determine hemodynamic effects and pharmacokinetic profiles of fentanyl with continuous infusion in 1- to 3-day-old newborn piglets. The piglets (n = 6) were administered a loading dose of fentanyl...