... therapeutic hypothermia compared to subjects without acute placental changes. Study Design: Among 500 subjects born at ≥36 weeks gestation with moderate or severe HIE enrolled in the High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) Trial, a placental pathologist blinded to clinical information...

...Hendrik S. Fischer; Nora J Reibel; Christoph Bührer; Christof Dame Background: Recombinant human erythropoietin (rhEPO) lost its role in minimizing red blood cell transfusion in very preterm infants after it had been associated with severe retinopathy of prematurity (ROP). Previous systematic...

...Dennis E. Mayock; Zimeng Xie; Bryan A. Comstock; Patrick J. Heagerty; Sandra E. Juul; on behalf of the Preterm Epo Neuroprotection (PENUT) Trial Consortium Introduction: The Preterm Erythropoietin (Epo) Neuroprotection (PENUT) Trial sought to determine the safety and efficacy of early high-dose Epo...

... of prematurity Oxygen saturation targeting Neonatal intensive care Neonatal networks Comparative analysis Erythropoietin The incidence of retinopathy of prematurity (ROP) varies considerably among centers, both within [ 1, 2 ] and between countries [ 3 ]. We recently reported that, for infants born...

... of hypoxia and brain trauma: erythropoietin and S100B. Methods: The study population consisted of 140 singleton, term neonates: 113 controls and 27 with birth asphyxia (2/3 criteria met: umbilical artery pH <7.10, base excess ≤12 mmol/L, and 5-min Apgar score <7). All deliveries were planned vaginal...

..., erythropoietin administration and blood transfusion were allowed according to the consensus in Japan. The hematological status was surveyed from birth to 12 postnatal weeks of age. The iron status was determined according to serum iron, unbound iron-binding capacity and serum ferritin. The definition...

.... Bevacizumab Bronchopulmonary dysplasia Erythropoietin Insulin-like growth factor Mortality Propranolol Oxygen saturation targets Retinopathy of prematurity Vascular endothelial growth factor Phase II ROP is marked by overproduction of VEGF leading to vasoproliferation [ 17 ] as a result...

...Hyun Ju Lee; Seong-Ho Koh; Ki-Min Song; In Joon Seol; Hyun-Kyung Park Background: The mTOR (mammalian target of rapamycin) signaling pathway is a master regulator of cell growth and proliferation in the nervous system. However, the effects of erythropoietin (EPO) treatment on the mTOR signaling...

...Lihua Zhu; Xiang Bai; Shiyu Wang; Yan Hu; Ting Wang; Lijuan Qian; Li Jiang Background: Recombinant human erythropoietin (rh-EPO) has been used as a drug to treat premature infant anemia for over a decade. In addition to its erythropoietic effect, rh-EPO has also been reported to have protective...

... and mortality. Hyperglycemia during pregnancy causes excessive fetal growth and chronic fetal hypoxia as reflected in increased erythropoietin (EPO) levels in amniotic fluid (AF). Objectives: We hypothesized that the degree of fetal hypoxia would correlate with fetal oxidative and nitrosative stress...

...Niti Rayjada; Lorayne Barton; Linda S. Chan; Salvador Plasencia; Manoj Biniwale; Kim Chi Bui Background: Despite advances in clinical care, the incidence of bronchopulmonary dysplasia (BPD) remains high in premature infants. Erythropoietin (EPO) is used for the treatment of anemia of prematurity...

...Christof Dame; Juliane Langer; Brigitte M. Koller; Jean-Claude Fauchère; Hans Ulrich Bucher Background: High-dose recombinant human erythropoietin (rEpo) has first been administered in clinical trials for neuroprotection in very preterm neonates at high risk of brain injury and in (near-) term...

...E.M. Anderson; D.R.E. Jones; D.T.Y. Liu; F. Broughton Pipkin Angiotensin affects the growth of many cell types and there have been suggestions that it could influence cells which respond to erythropoietin. During first trimester, human fetal haematopoietic cells are exquisitely responsive...

...Fujio Kakuya; Masaru Shirai; Masashi Takase; Noriyuki Ishii; Akimasa Okuno Erythropoietin (EPO) levels in amniotic fluid and serum were measured in hypoxic (fraction of inspired oxygen, FiO 2 , 0.09) and posthypoxic (following a 24-hour period of hypoxia, FiO 2 0.09) fetal rats on day 21...

...Didier J. Lemery; Joaquin Santolaya; Anne F. Serre; Stephanie Denoix; Guy H. Besse; Philippe C. Vanlieferinghen; Marie J. Bezou; Ginette Gaillard; Bernard Jacquetin Serum erythropoietin (Epo) concentration was compared prenatally in adequate (AGA) and small for gestational age (SGA) fetuses. Fifty...

...M.D. Rollins; A.P. Maxwell; M. Afrasiabi; H.L. Halliday; T.R.J. Lappin We have investigated the relationship between erythropoietin (Epo) and pH, PaO 2 and haematocrit in 100 cord blood samples obtained at Caesarean section prior to labour. Of 82 term ( > 37 weeks) infants, 64 were appropriately...

...John A. Widness; Siegfried M. Pueschel; John C. Pezzullo; Gisela K. Clemons Plasma erythropoietin (Ep) was determined in umbilical cord blood in 18 infants with Down’s syndrome. The 16 infants with Down’s syndrome who were delivered after labor had significantly elevated plasma Ep levels compared...

...Charles Peters; Michael K. Georgieff; Pedro A. de Alarcon; Robert T. Cook; Leon F. Burmeister; Lance S. Lowe; John A. Widness Erythropoietin, the primary stimulator of erythropoiesis, represents an important potential therapy for the anemia of prematurity. Enhancement of the therapeutic benefit...

... and fetal rat serum after 2 h of surviving than in cultures with fetal rat serum sampled at time 0. These results suggest a release of erythropoietin or erythropoietin-like substances in response to a short hypoxic phase following the parting of the fetus with the mother and preceding the autonomous...

... maternal stress), leads to an increase in serum erythropoietic activity detected with an in vitro fetal liver bioassay. This increase in serum erythropoietin-like substance may be related with the premature onset of bone marrow red cell formation observed under similar experimental conditions...