...D.S. Semama; M. Thonney; J.-P. Guignard In the newborn rabbit, acute normocapnic hypoxemia increases the renal vascular resistance, leading to renal hypoperfusion and decreased glomerular filtration rate. Endothelin is a potent vasoconstrictor peptide, produced by vascular endothelial cells, which...

...D. Dunbar Ivy; Dong-Seok Lee; Robyn L. Rairigh; Thomas A. Parker; Steven H. Abman Background: Endothelin-1 (ET-1) contributes to the regulation of pulmonary vascular tone in the normal ovine fetus and in models of perinatal pulmonary hypertension. In the fetal lamb lung, the effects of ET-1 depend...

...Bhagya L. Puppala; George Matwyshyn; Shaifali Bhalla; Anil Gulati Morphine tolerance Central nervous system Neonatal rats Endothelin [ 125 I]Endothelin-1 binding [ 35 S]Guanosine triphosphate-=γS binding 3 02 2004 20 04 2004 18 8 2004 © 2004 S. Karger AG, Basel...

...Dunbar Ivy; Kazuhiko Tanzawa; Steven H. Abman Endothelin 1 (ET-1) is a potent vasoconstrictor and smooth muscle comitogen that is produced by endothelin-converting enzyme 1 (ECE-1) in endothelium and smooth muscle of the vascular wall in adult pulmonary arteries. However, little is known about...

..., and the contraction has been ascribed to endothelin-1 (ET-1). We have now studied these vasoeffector mechanisms before term (0.7 and 0.65 gestation) with the objective of determining whether their activity correlates with the development of susceptibility to oxygen changes. Experiments were carried out at neonatal PO...

...) was examined. PASMC were exposed to different oxygen tensions and the cells were counted electronically and the conditioned media analyzed for basic fibroblast growth factor (bFGF), endothelin-1 (ET-1), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF). The effect...