...Gabriel Osuide; Charles Wambebe; Christopher O. Ikediobi; Helen O. Kwanashie The effects of maternal cimetidine pretreatment at different dose levels during lactation, on drug metabolism, were investigated in mouse dams and recently weaned pups. Aminopyrine N-demethylase, aniline hydroxylase...

...Margareta Eriksson; Charlotte Catz; Sumner J. Yaffe Protein deficiency in post-suckling rats produced changes in the activity of hepatic drug-metabolizing enzymes. Significant decreases occurred in the N -demethylation of aminopyrine, in the azo-reduction of neoprontosil and in sulfokinase activity...

...T.K. Basu; J.W.T. Dickerson; D.V. Parke The activities of the drug metabolizing enzymes biphenyl-4-hydroxylase, p -nitrobenzoate reductase, 4-methyl umbelliferone glucuronyl transferase and the amounts of cytochrome P-450, DNA and microsomal protein have been determined at 6,12,18 and 21 days...

... exist at the prenatal stage. These differences may contribute to individual pharmacological and/or toxicological responses in the fetus. Fetus Liver Cytochrome P450 Drug metabolism Original Paper Biol Neonate 2001;80:193 201 Cytochrome P450 3A Expression in the Human Fetal Liver: Evidence...