... and mortality, without evidence of long-term neurological harm. However, no studies have been powered to look for important adverse long-term neurological effects. Of the 2 systemic corticosteroids assessed, most effects relate to dexamethasone and not to hydrocortisone, but hydrocortisone in the first week...

... treatment reduces chronic lung disease, the combination of death and chronic lung disease at both 28 days and 36 weeks' corrected age, and the need for later rescue dexamethasone. Adverse effects include hyperglycemia, hypertension, hypertrophic cardiomyopathy, and severe retinopathy of prematurity...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Betamethasone Dexamethasone Cortisol 11β-Hydroxysteroid dehydrogenase Intrauterine growth restriction Preterm birth...

...Marrit M. Hitzert; Annemiek M. Roescher; Arend F. Bos Background: High-dose dexamethasone (DXM) treatment of preterms at risk of bronchopulmonary dysplasia leads to a deterioration in quality of their general movements (GMs). It is unknown whether low-dose DXM affects GM quality similarly...

... corticosteroids and phosphodiesterase-5 (PDE-5) inhibitors have a beneficial effect on pulmonary vascular development in CDH lungs. Methods: We induced CDH in fetal rats by giving nitrofen. We then exposed them to dexamethasone or to sildenafil. We separated them into three groups: (1) DEX, 4 pregnant rats...

...Kristin Tanney; Jonathan Davis; Henry L. Halliday; David G. Sweet Background: Bronchopulmonary dysplasia (BPD) is a major respiratory complication of extreme prematurity. Dexamethasone is effective in reducing ventilation requirements in babies with BPD, but follow-up studies have raised concerns...

... in pulmonary development. Objectives: The purpose of this study was to compare pulmonary VEGF expression in newborn rats that were exposed to antenatal betamethasone versus dexamethasone and to evaluate its impact on the alveolarization period of rats (0–14 days of life). Methods: Betamethasone, dexamethasone...

... was to compare pulmonary VEGF expression in newborn rats that were exposed to antenatal betamethasone versus dexamethasone under normoxia, hypoxia and oxidative stress, and to evaluate its impact on alveolarization. Betamethasone, dexamethasone or equivalent saline solution (control group) was administered...

...Lex W. Doyle; Richard A. Ehrenkranz; Henry L. Halliday Background: Dexamethasone has powerful anti-inflammatory effects and has been used to treat established bronchopulmonary dysplasia (BPD), but it is uncertain whether the benefits outweigh the risks of treatment. Objectives: To determine...

...Lex W. Doyle; Richard A. Ehrenkranz; Henry L. Halliday Background: Dexamethasone treatment started soon after birth is controversial. Objectives: To determine if postnatal dexamethasone treatment during the first week of life is beneficial in preventing bronchopulmonary dysplasia (BPD) in preterm...

..., a significant growth response was measured (133.2 ± 4.8%). Expression of Ad-AT 2 alone induced a ∼20% increase in total cellular protein content, which was unaffected by addition of AngII. Neither corticosterone (1 µmol/l) nor dexamethasone (1 µmol/l) had any significant effect on the AT 1 - or AT 2 -mediated...

...Nancy S. La Mear; Scott S. MacGilvray; Thomas F. Myers Clinical trials have shown dexamethasone’s beneficial effects on the pulmonary status of infants with bronchopulmonary dysplasia; however, hypertrophic cardiomyopathy has been a reported complication of this therapy with no known mechanism. Our...

...William H. Meetze; Vivek Shenoy; Gaines Martin; Pierre Musy; Josef Neu The ontogeny of small intestinal glutaminase (GA) and glutamine synthetase (GS) was studied with relation to the maternal administration of dexamethasone (DEX). Pregnant Sprague-Dawley rats were administered 0.2 mg/kg of DEX...

...Naoki Yokoyama; Satoshi Takada; Yoshiyuki Uetani; Hajime Nakamura To determine the effects of maternal administration of dexamethasone (DEX) and thyrotropin-releasing hormone (TRH) on fetal lung maturation, 16 pregnant rats were divided into the following four groups: 20 μg/kg TRH twice a day...

...T.A. Slotkin; S.E. Lappi; E.C. McCook; M.I. Tayyeb; J.P. Eylers; F.J. Seidler Although glucocorticoids slow the development of most cell types, they have been hypothesized to promote the differentiation of catecholaminergic cells. In the current study, pregnant rats were given dexamethasone...

...J. Schwarze; P. Bartmann The lymphocyte proliferative response to mitogen stimulation was measured in cord blood cultures of term and preterm neonates. The lymphocyte proliferative response increased 150-to 400-fold above baseline after stimulation with mitogens. Dexamethasone suppressed...

...Lynne L. Levitsky; Deborah V. Edidin; Julie A. Menella; Nanci H. Spaulding; Lee-Chin Hsieh Renal and hepatic levels of the rate-limiting gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) were determined in control and intrauterine growth-retarded rate neonates and dams. Dexamethasone...

...María C. Juanes; Carmen Arizmendi; José M. Medina The effect of maternal treatment with dexamethasone on blood PO 2 , PCO 2 , pH and lactate concentrations and on lung phospholipid content in premature newborn rats during the early neonatal period was studied. The postnatal hypoxia shown...

...Naoki Nishida; Taishi Takeuchi During treatment of primary cultured hepatocytes with dexamethasone for several hours, cyclic AMP formation and glycolysis by glucagon increased dose dependently. In the cells pretreated with dexamethasone, the output of intracellular cyclic AMP increased...

..., hypothalamus), hypophyses, adrenals and plasma of 21-day-old rat fetuses from mothers which were given either plain tap water or water containing dexamethasone acetate (10 μg/ml) from day 15 to 21 of gestation. Dexamethasone induced drastic reduction of body weight (––66% vs. controls), severe atrophy...