...Srirupa Hari Gopal; Robert Tillman; James D. Hammond II; Joseph L. Hagan; Sharada H. Gowda; Nidhy P. Varghese; Caraciolo J. Fernandes Introduction: While a patent ductus arteriosus (PDA) helps offload the right ventricle in the acute congenital diaphragmatic hernia (CDH)-associated pulmonary...

...Jamie Gilley; Sandra K. Hanneman; Madelene J. Ottosen; Binoy Shivanna; Sundeep Keswani Introduction: Congenital diaphragmatic hernia (CDH) is a complex congenital disorder, characterized by pulmonary hypertension (PH) and hypoplasia. PH secondary to CDH (CDH-PH) features devastating morbidity...

...Emily J.J. Horn-Oudshoorn; Alisa M. Blekherov; Gerbrich E. van den Bosch; Sinno H.P. Simons; Ronny Knol; Arjan te Pas; Irwin K.M. Reiss; Philip L.J. DeKoninck Introduction: Infants with congenital diaphragmatic hernia (CDH) are commonly intubated immediately after birth. Consensus on whether...

... in infants with congenital diaphragmatic hernia (CDH). Methods: A single-center retrospective cohort study was conducted in consecutive infants with isolated CDH with continuous OSI measurements collected in the first 24 h after birth between June 2017 and July 2021. Outcomes of interest were pulmonary...

... index (OSI) is an alternative that allows for continuous noninvasive monitoring, but evidence for clinical use in critically ill neonates is scarce. The aim of this study was to evaluate the OSI as compared to the OI in term neonates with a congenital diaphragmatic hernia (CDH). Methods: A single-center...

...Dalya Munves Ferguson; Vikas S. Gupta; Pamela A. Lally; Matias Luco; KuoJen Tsao; Kevin P. Lally; Neil Patel; Matthew T. Harting; for The Congenital Diaphragmatic Hernia Study Group Introduction: Pulmonary hypertension (PH) is the major pathophysiologic consequence of congenital diaphragmatic...

...Anna Claudia Massolo; Anshuman Paria; Lindsey Hunter; Emma Finlay; Carl F. Davis; Neil Patel Background: Congenital diaphragmatic hernia (CDH) is an important cause of mortality and morbidity in the neonatal period. Pulmonary hypertension and pulmonary hypoplasia are key pathological findings...

...Kitty G. Snoek; Anne Greenough; Joost van Rosmalen; Irma Capolupo; Thomas Schaible; Kamal Ali; René M. Wijnen; Dick Tibboel Background: Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly with significant mortality. Objectives: The aim of this study was to determine if there were...

...Eva Van Ginderdeuren; Karel Allegaert; Herbert Decaluwe; Jan Deprest; Anne Debeer; Marijke Proesmans Background: Congenital diaphragmatic hernia (CDH) is an abnormal development of the diaphragm leading to high neonatal mortality and morbidity. Beyond the neonatal period, prospective data...

... tailor exogenous surfactant treatment in neonatal lung diseases. [email protected] 3 6 2016 Congenital diaphragmatic hernia Disaturated phosphatidylcholine Lung water Meconium aspiration syndrome Newborn infant Phosphatidylcholine Respiratory distress syndrome Stable...

...Kitty G. Snoek; Irwin K.M. Reiss; Anne Greenough; Irma Capolupo; Berndt Urlesberger; Lucas Wessel; Laurent Storme; Jan Deprest; Thomas Schaible; Arno van Heijst; Dick Tibboel; for the CDH EURO Consortium In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized...

...Kitty G. Snoek; Irma Capolupo; Annabella Braguglia; Lucia Aite; Joost van Rosmalen; Laura Valfrè; René M. Wijnen; Pietro Bagolan; Dick Tibboel; Hanneke IJsselstijn Background: Since mortality in congenital diaphragmatic hernia (CDH) is decreasing, morbidity such as neurodevelopmental outcome...

...Javier Kattan; Carlos Céspedes; Alvaro González; Carlos P. Vio Background: A predictor of neonatal mortality in infants with congenital diaphragmatic hernia (CDH) is disrupted pulmonary vascular development, clinically expressed as pulmonary hypertension. Objective: To determine if prenatal...

... of this study was to evaluate our experience with lung biopsy through a minithoracotomy as an alternative for obtaining postmortem tissue when full autopsy is refused in congenital diaphragmatic hernia (CDH) patients. Methods: Within 2 h of death we routinely asked parents for permission to perform an autopsy...

... to assess whether increasing PEEP during resuscitation in CDH infants might restore their lung function following pancuronium administration and avoid having to increase their peak inflating pressure. Approximately 1 in 3,000 live births have a congenital diaphragmatic hernia (CDH) [ 1...

...Neil Patel Background: Pulmonary hypertension and secondary cardiac dysfunction are important contributors of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Milrinone, a phosphodiesterase-3 inhibitor, may be useful in this setting for its combined actions...

...L. van den Hout; I. Reiss; J.F. Felix; W.C.J. Hop; Pamela A. Lally; Kevin P. Lally; D. Tibboel; for the Congenital Diaphragmatic Hernia Study Group Background: Congenital diaphragmatic hernia (CDH) is associated with a mortality rate of 10–35% in live-born infants. Moreover, CDH survivors have...

...I. Reiss; T. Schaible; L. van den Hout; I. Capolupo; K. Allegaert; A. van Heijst; M. Gorett Silva; A. Greenough; D. Tibboel; for the CDH EURO consortium Congenital diaphragmatic hernia (CDH) is associated with high mortality and morbidity. To date, there are no standardized protocols...

...Kamalesh Pal; D.K. Gupta Background: Pulmonary growth in the survivors of congenital diaphragmatic hernia (CDH) still remains an intriguing issue. In the literature there are conflicting reports on pulmonary vascular growth in CDH. Objective: In a cohort of CDH patients treated without...

... had pulmonary hypoplasia (decreased lung/body weight), lung hypocellularity (low DNA content) and cellular atrophy (low protein/ DNA and phospholipid/DNA) on gestational days 19 and 21. Treated animals with congenital diaphragmatic hernia (CDH) also had cell atrophy and surfactant immaturity...