... mouse lung, and to compare the gene expression changes after reoxygenation in 60% O 2 versus air across the different time points. The selected genes have important functions related to mediators of inflammation and injury, apoptosis, cell cycle renewal, DNA repair and vascular development; processes...

... and the third 24 h after the second dose. The pups were sacrificed on postnatal day 10, their brains harvested and evaluated for infarct volume and neuronal apoptosis. Results: Percent infarcted brain volume was significantly reduced in pups receiving the drugs (either magnesium sulfate, melatonin...

... have demonstrated that postasphyxial serum from neonates with asphyxia may result in apoptosis of renal tubular cells. However, the mechanisms that mediate renal tubular cell apoptosis induced by postasphyxial serum remain poorly understood. Objectives: In this report we investigate the intracellular...

... and mortality. There is a lack of evidence investigating the neurotoxic effects of neonatal magnesium (Mg) exposure on the developing brain, specifically in terms of neurodevelopmental apoptosis, a cell-killing phenomenon known to be potentiated by other drugs with mechanisms of action at Mg-binding sites (i.e...

... apoptosis, these alterations may initiate a cascade of reactions that lead to apoptotic cell death. Objectives: This study tests the hypothesis that hypocapnia results in increased expression of the pro-apoptotic protein Bax, fragmentation of DNA and membrane lipid peroxidation in cerebral cortical...

... infection and hypoxia. Objectives: We aimed to study the effects of in vitro hypoxia and heat shock (HS) on normal adult and newborn neutrophil migration (CD11b) and persistence (apoptosis) following lipopolysaccharide (LPS) stimulation. Methods: The mechanism for altered LPS responses was assessed...

... exerts a neuroprotective effect against hypoxic-ischemic brain injury, at least partially, via the differential regulation of the expression of genes involved in apoptotic process. Erythropoietin Bcl-2 family Neonatal rat Hypoxic-ischemic brain injury Apoptosis DP5 9 05 2005 12 09...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Apoptosis Lung injury Neutrophils Newborn piglet Pulmonary hypertension Immunoglobulin G Original Paper Biol Neonate 2005;87:221 228 DOI: 10.1159/000083371 Received...

... intestinal injury was due to increased apoptosis of the intestinal mucosa in young mice and whether pre-treatment of the animals with recombinant human insulin-like growth factor-I (IGF-I), a known anti-apoptotic factor, could protect the intestinal cells from H/R-induced apoptosis or intestinal injury...

... 7 2 2005 Bilirubin Astrocyte Apoptosis Cytotoxicity © 2005 S. Karger AG, Basel 2005 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means...

... and chronic lung disease. Apoptosis of neutrophils is impaired in newborns, leading to reduced clearance of activated cells and possibly contributing to the susceptibility of infants to these inflammatory diseases. Objectives: In the present studies, we investigated the hypothesis that ibuprofen reduces...

...Chih-Cheng Luo; Hsiang-Hung Shih; Cheng-Hsun Chiu; Wei-Chun Ma; Hui-Ying Chung The pathogenesis of necrotizing enterocolitis (NEC) is unknown. Ischemia and reperfusion (I/R) injury has been considered to be a major contributing factor. More recent reports have noted that apoptosis is a significant...

... Brain Caspase-3 Neonate Immature brains Rat Hypoxia-ischemia Apoptosis Original Paper Biol Neonate 2003;84:164 171 DOI: 10.1159/000071952 Postischemic Hyperthermia Induced Caspase-3 Activation in the Newborn Rat Brain after Hypoxia-Ischemia and Exacerbated the Brain Damage Hirotsugu Fukuda...

... neuroprotective effect of Epo in this model of neonatal hypoxic-ischemic brain injury. To our knowledge, this is the first study that demonstrates a protective effect of Epo against hypoxia-ischemia in the developing brain. Erythropoietin Apoptosis Neonatal rat Hypoxia Ischemia Infarct volume Brain...

... and alveolar macrophages, with later architectural epithelial and endothelial cell damage. Recently, apoptosis of type 2 pneumocytes in the lung of preterm neonates with acute and chronic lung disease has been examined and apoptosis of mesenchymal cells was detected in the chronic stage of bronchopulmonary...

... levels decreased. We conclude that there is a critical threshold value of oxidative metabolism beyond which there are progressive changes in the cortical neuronal cells, leading to DNA fragmentation. Apoptosis Hypoxia DNA fragmentation Brain Newborn 23 3 2001 © 2001 S. Karger AG...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Caspase Neonatal rat Brain Hypoxia Ischemia Apoptosis Poly(ADP-ribose) polymerase Inhibitor of caspase-activated...

...) receptor activity from maternal separation and sensory isolation leads to increased apoptosis in multiple areas of the immature brain. On the other hand, exposure to repetitive pain may cause excessive NMDA/excitatory amino acid activation resulting in excitotoxic damage to developing neurons...

... accumulation, apoptosis and upregulation of antioxidant enzyme activity. To define the effects of NO on neutrophils from young piglets and its relationship to lung neutrophil dynamics during hyperoxia we exposed thirty piglets to room air (RA), RA+NO (50 ppm NO), O 2 (FiO 2 ≥0.96) or O 2 +NO for 5 days. Ten...

... NO production by neonatal porcine pulmonary artery smooth muscle cells (PASMCs) varied with oxygen tension in vitro, and (2) the effect of exogenous NO and inducible NO synthase (iNOS) stimulators and inhibitors on PASMC proliferation and apoptosis. PASMCs were exposed to different conditions (varying PO 2...