Background: Prolidase, a specific iminopeptidase involved in collagen turnover, is especially active in growing tissues. Objectives: To investigate the relationship between cord blood prolidase activity and both birth weight and gestational age. Methods: Cord blood was collected consecutively from 50 healthy newborns (35 term, 15 preterm). Prolidase activity was measured in the samples using standard methods. Results: Themean ± SD cord blood prolidase activity was 41.4 ± 6.9 U/l in term infants and 35.2 ± 8.0 U/l in preterm infants and these were significantly different (p < 0.01). There were positive correlations between cord blood prolidase and both birth weight (r = 0.533, p < 0.01) and gestational age (r = 0.806, p < 0.01). Conclusion: Cord blood prolidase activity may be a good indicator of fetal maturation and gestational age.

Keywords:
Prolidase, Cord blood, Birth weight, Gestational age
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© 2008 S. Karger AG, Basel
2008
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