Lewis (Le) and Secretor (Se) gene effects on postnatal change in Lewis antigens are described based on the quantitative analysis of Lewis antigens in blood. Genuine Lewis blood types were determined by Le and Se genotyping in DNA samples obtained from umbilical cord blood and infant blood. Lewisa (Lea) and Lewisb (Leb) antigen levels were measured by a time-resolved fluoroimmunoassay. We found that Lewis phenotypes in infants over 9 months of age agreed with the genuine types. In cord blood, the dosage effect of the Se gene on antigen levels was observed, but the Le gene effect was not observed. Both Se and Le gene effects were observed in newborn babies’ blood 3–6 days after birth.

Keywords:
Lewis blood type, Postnatal development, Lewis antigen level, Lewis gene, Secretor gene, Cord blood, Infant blood
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© 2001 S. Karger AG, Basel
2001
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