Insulin (I) plays a crucial role in the maturation of the perinatal brain, and it may also be involved in the pathogenesis of neonatal brain injuries. The aim of the present study was to reveal the effect of neonatal asphyxia on the regulation of I and glucose (G) metabolism in plasma and cerebrospinal fluid (CSF) in newborn piglets. The I concentrations were measured by radioimmunoassay, while the G levels were analyzed by the G oxidase method during three phases (basal, critical, recovery) of bilateral pneumothorax in newborn piglets. We observed a significant hyperinsulinism (p < 0.001) both in plasma and CSF and a mild hypoglycemia (p < 0.05) during the recovery period. Postasphyxial G infusion (1.1 M, 10 ml·kg––1) amplified the hyperinsulinism. The IcsF/piasma ratio (mean ± SEM; n = 16) was decreasing during cardiovascular failure (0.09 ± 0.02; NS) as compared with the initial value (0.12 ± 0.04), then it returned to basal values by 60min (0.14 ± 0.04; NS), and increased significantly 180min (0.40 ± 0.14; p < 0.05) after resuscitation of the piglets. There was a similar increase in GcsF/piasma ratio in asphyxiated animals at the end of experiments (0.99 ± 0.15 vs. initial 0.76 ± 0.05; p < 0.05). In conclusion, neonatal asphyxia resulted in plasma and CSF hyperinsulinism which may alter hypoxic-ischemic cerebral damages.

Keywords:
Cerebrospinal fluid, Glucose, Hyperinsulinism, Asphyxiated piglets, Insulin, Neonatal asphyxia
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© 1996 S. Karger AG, Basel
1996
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