The effect of vitamin D supplementation on inorganic sulfate metabolism was examined in very low birth weight (< 1,500 g) infants at biweekly intervals after birth until 6 weeks of postnatal age. Baseline serum sulfate concentrations were significantly higher in all infants (471 ± 24 μmol/l, n = 80) than in adults (299 ± 25 μmol/l, n = 17). In controls, the levels did not change significantly over the ensuing 6 weeks, although serum creatinine declined. Urinary sulfate excretion rose significantly to near adult levels by 2 weeks. Both urine and serum sulfate were correlated with weight gain but not with estimated glomerular filtration rate, suggesting that factors other than renal clearance have a preponderant influence on serum sulfate in these infants. At 6 weeks, the mean serum sulfate in the high-dose group (receiving 2,170 ± 23 U/day of vitamin D, n = 41) was significantly higher than in controls (receiving 360 ± 22 U/day, n = 40). In all infants, there was a significant correlation (r = 0.36, p < 0.001) between serum sulfate and 25(OH)-vitamin D concentrations, but not other analytes or clinical variables, suggesting that vitamin D may be one of the factors modulating sulfate metabolism in the newborn period.

Keywords:
Inorganic sulfate, Very low birth weight infant, Prematurity, Creatinine, Serum, Urine
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© 1990 S. Karger AG, Basel
1990
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