Using a commercial pulsed Doppler (PD) system we measured commoncarotid artery (CCA) flow velocities in 19 healthy and 6 stable preterm infants and computed volume flow rates based on the time-averaged flow velocities and vessel diameter. The mean (± SEM) time-averaged CCA velocities in the term and preterm infants were 33.04 ± 3.0 and 23.3 ± 1.3 cm·s-1 respectively. The total flow volume was significantly higher in the term as opposed to preterm infants: 126 ± 11.2 vs. 55.6 ± 7.7 ml/min (p < 0.01). The body-weight-normalized flow volume, however, was not statistically significantly different between the two groups of infants. Several technical and practical limitations still exist to compute cerebral blood flow (CBF) volume accurately. In a puppy model we measured the CCA flow volume by electromagnetic flowmeter technique, and the PD device simultaneously. The correlation coefficient between 32 pairs of measurements was 0.93 (p < 0.005). We conclude that commercial PD devices provide accurate velocity data, and under experimental conditions, the computed volume flow rates are accurate. Although in clinical situations reasonably accurate CBF values can be estimated, refinements in technology are needed to adopt this method as a possible means of measuring CBF at the bedside.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.