Neonates manifest more hemorrhagic tendencies when exposed to either acetylsalicyclic acid (ASA) or indomethacin in comparison to adults. We therefore assessed the susceptibility of neonatal and adult platelets to the effects of these cyclooxygenase inhibitors in vitro. Baseline thromboxane B2 production in response to thrombin was similar in platelets from the adult and neonate. Following exposure to varying concentrations (0.5–100 μM) of either ASA or indomethacin, platelet thromboxane B2 was inhibited to a similar extent in both adult and neonatal platelets. Our study demonstrates that the enhanced tendency to bleeding observed in the neonate following exposure to ASA or indomethacin is not due to an enhanced susceptibility of the neonatal platelet enzyme to the effects of cyclooxygenase inhibition.

Keywords:
Acetylsalicyclic acid, Indomethacin, Platelet thromboxane, Newborn, Bleeding
This content is only available via PDF.
© 1985 S. Karger AG, Basel
1985
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.