Cardiac function and peripheral blood flows were measured before and during single intravenous injections of dopamine (2–25 μg/kg) in developing and mature swine anesthetized with pentobarbital. A positive inotropic effect was observed in even the youngest swine. Renal vasoconstriction was observed even after low doses of dopamine in animals younger than 1 month of age, and femoral vasoconstriction in animals younger than 2 weeks of age, unless α-adrenergic receptors were blocked by phentolamine. We concluded that the vasodilator responses to dopamine are slower to develop in the renal than in the femoral circulation.

Keywords:
Carotid blood flow, Dopamine, Femoral blood flow, Inotropic effect, Phentolamine, Postnatal development, Renal blood flow
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© 1983 S. Karger AG, Basel
1983
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