Polycythemia induced by hypoxia in pregnant mice caused a marked reduction in the total number of erythroid precursors in the 10th, 11th, and 12th day embryonic livers, as compared with controls. In addition, the maturation of the erythroid precursors in the 11th day embryonic livers of polycythemic mice was markedly inhibited in comparison with that of controls, whereas on the following days of gestation the erythropoiesis in embryonic livers of both polycythemic and control mice exhibited a similar pattern. It is suggested that the reduced erythropoiesis in the 11th day embryonic liver of polycythemic mothers provides a stimulation for embryonic erythropoietin production. Subsequently, it triggers the maturation of progenitor erythroid cells in the livers and induces an increased erythropoietic activity in the plasma of 12th and 13th day pregnant polycythemic mice as was observed in our previous study.

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