Hepatic uridine diphospho(UDP)glucuronosyl transferase activity was measured in growing male rats to gain the developmental activity pattern of this enzyme catalyzing conjugation of xenobiotics and endogenous substrates. The activity was at a very low level at the age of 14 days showing a 10-fold increase to the age of 72 days whereafter a slight decrease of activity was observed. Simultaneously there was about 30% increase in the hepatic postmitochondrial supernatant protein content. The highly enhanced UDPglucuronosyl transferase activity during the growth may be caused by increased synthesis of enzyme protein or by changes in the micro-environment of the enzyme.

Keywords:
Glucuronidation, Growth, Liver
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© 1977 S. Karger AG, Basel
1977
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