A comparative histological and histochemical study on undecalcified frozen sections of the tibial growth plate was performed on fetuses, newborn infants and children. Three types of growth cartilage were described: early fetal, late fetal to newborn, and cartilage of 5- to 10-year-old children. A decrease of cellularity and in increase of matrix, a thickening of the intercolumnar septa, change in metachromasia of the septa and of the basal zone appear with age. A decrease in size of the hypertrophic cells from the early fetal to the newborn period is observed. A system of canals with vascular anastomoses across the plate is well developed in the late fetal-newborn period. Age-dependent change in permeability and in distribution of the oxygen tensions within the plate were suggested. Signs of growth arrest were found in several newborns with important general pathologic findings.

Keywords:
Growth cartilage, Fetus, Newborn, Metachromasia, Cartilage canals
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© 1973 S. Karger AG, Basel
1973
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