The activities of the drug metabolizing enzymes biphenyl-4-hydroxylase, p-nitrobenzoate reductase, 4-methyl umbelliferone glucuronyl transferase and the amounts of cytochrome P-450, DNA and microsomal protein have been determined at 6,12,18 and 21 days in the livers of rats reared from birth in large (15 pups) and small (3 pups) litters. Undernutrition retarded the gain in liver weight more than that of body weight during the first 12 days. It did not, however, change the concentration per unit weight of liver of any of the constituents measured. Phenobarbital did not change the body or liver weight in either group, but increased the amount of microsomal protein at 12 days and doubled the amount of DNA per 100 g body weight in both groups at 12 and 21 days. The percentage increase in enzyme activity caused by phenobarbitone was greater in the undernourished animals than in the controls.

Keywords:
Undernutrition, Drug metabolism, Liver, Microsomal enzymes, Enzyme induction, Cytochrome P-450
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© 1973 S. Karger AG, Basel
1973
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