Introduction: Body composition, specifically fat-free mass (FFM), of preterm infants is associated with improved neurodevelopmental outcomes. Little is known about body composition of preterm infants after discharge. Preterm body composition was measured by air displacement plethysmography (ADP) at two time points, inpatient (35–40 weeks postmenstrual age [PMA]) and outpatient (48–58 weeks PMA), with neonatal factors and neurodevelopmental testing at 4–6 months corrected age. We hypothesized increased FFM is positively associated with neurodevelopment. Methods: From 2007 to 2011, 510 infants admitted to the Medical University of South Carolina’s neonatal intensive care unit underwent ADP. A total of 379 of 510 (74%) had anthropometrics at birth, an ADP scan with FFM, fat mass, fat percent z-scores, and an outpatient neurodevelopmental evaluation (CAT/CLAMS, Peabody Gross Motor). Variables were compared using multivariate analyses for body composition measurements. Results: The infants were 32 ± 4.8 weeks gestational age at birth with an average birth weight of 1,697 ± 932 g. Most (56%) infants received maternal milk at discharge. CAT, CLAMS, and gross motor scores had positive correlations with FFM z-scores at inpatient and outpatient ADP (p < 0.05). Receiving maternal milk at discharge was positively associated with cognitive (β = 0.22, p < 0.05) and language scores (β = 0.26, p < 0.05). Conclusion: Increased FFM is associated with improved cognitive, language, and gross motor testing. Maternal milk was positively associated with language and cognitive scores.

1.
Cordova
EG
,
Belfort
MB
.
Updates on assessment and monitoring of the postnatal growth of preterm infants
.
Neoreviews
.
2020
;
21
(
2
):
e98
108
.
2.
Hamatschek
C
,
Yousuf
EI
,
Möllers
LS
,
So
HY
,
Morrison
KM
,
Fusch
C
.
Fat and fat-free mass of preterm and term infants from birth to 6 months: a review of current evidence
.
Nutrients
.
2020
;
12
(
2
):
288
.
3.
Bua
J
,
Risso
FM
,
Bin
M
,
Vallon
F
,
Travan
L
,
Paviotti
G
.
Association between body composition at term equivalent age and Bayley scores at 2 years in preterm infants
.
J Perinatol
.
2021
;
41
(
8
):
1852
8
.
4.
Ramel
SE
,
Gray
HL
,
Christiansen
E
,
Boys
C
,
Georgieff
MK
,
Demerath
EW
.
Greater early gains in fat-free mass, but not fat mass, are associated with improved neurodevelopment at 1 Year corrected age for prematurity in very low birth weight preterm infants
.
J Pediatr
.
2016
;
173
:
108
15
.
5.
Bergner
EM
,
Shypailo
R
,
Visuthranukul
C
,
Hagan
J
,
O'Donnell
AR
,
Hawthorne
KM
.
Growth, body composition, and neurodevelopmental outcomes at 2 Years among preterm infants fed an exclusive human milk diet in the neonatal intensive care unit: a pilot study
.
Breastfeed Med
.
2020
;
15
(
5
):
304
11
.
6.
Pfister
KM
,
Zhang
L
,
Miller
NC
,
Ingolfsland
EC
,
Demerath
EW
,
Ramel
SE
.
Early body composition changes are associated with neurodevelopmental and metabolic outcomes at 4 years of age in very preterm infants
.
Pediatr Res
.
2018
;
84
(
5
):
713
8
.
7.
Norris
T
,
Ramel
SE
,
Catalano
P
,
Caoimh
CN
,
Roggero
P
,
Murray
D
.
New charts for the assessment of body composition, according to air-displacement plethysmography, at birth and across the first 6 mo of life
.
Am J Clin Nutr
.
2019
;
109
(
5
):
1353
60
.
8.
Roggero
P
,
Giannì
ML
,
Amato
O
,
Orsi
A
,
Piemontese
P
,
Cosma
B
.
Postnatal growth failure in preterm infants: recovery of growth and body composition after term
.
Early Hum Dev
.
2008
;
84
(
8
):
555
9
.
9.
Cerasani
J
,
Ceroni
F
,
De Cosmi
V
,
Mazzocchi
A
,
Morniroli
D
,
Roggero
P
.
Human milk feeding and preterm infants’ growth and body composition: a literature review
.
Nutrients
.
2020
;
12
(
4
):
1155
.
10.
Deoni
SC
,
Dean
DC
,
Piryatinsky
I
,
O'Muircheartaigh
J
,
Waskiewicz
N
,
Lehman
K
.
Breastfeeding and early white matter development: a cross-sectional study
.
Neuroimage
.
2013
;
82
:
77
86
.
11.
Lucas
A
,
Morley
R
,
Cole
TJ
,
Lister
G
,
Leeson-Payne
C
.
Breast milk and subsequent intelligence quotient in children born preterm
.
Lancet
.
1992
;
339
(
8788
):
261
4
.
12.
McCurdy
M
,
Bellows
A
,
Deng
D
,
Leppert
M
,
Mahone
E
,
Pritchard
A
.
Test-retest reliability of the Capute scales for neurodevelopmental screening of a high risk sample: impact of test-retest interval and degree of neonatal risk
.
J Neonatal Perinatal Med
.
2015
;
8
(
3
):
233
41
.
13.
Tavasoli
A
,
Azimi
P
,
Montazari
A
.
Reliability and validity of the Peabody Developmental Motor Scales-second edition for assessing motor development of low birth weight preterm infants
.
Pediatr Neurol
.
2014
;
51
(
4
):
522
6
.
14.
Macias
MM
,
Saylor
CF
,
Greer
MK
,
Charles
JM
,
Bell
N
,
Katikaneni
LD
.
Infant screening: the usefulness of the Bayley infant neurodevelopmental screener and the clinical adaptive test/clinical linguistic auditory Milestone scale
.
J Dev Behav Pediatr
.
1998
;
19
(
3
):
155
61
.
15.
Accardo
P
,
Capute
A
The Capute Scales: Cognitive Adaptive Test/Clinical Lingustic and Auditory Milestone Scale
Brooks Publishing
2005
. p.
136
.
16.
Kube
DA
,
Wilson
WM
,
Petersen
MC
,
Palmer
FB
.
CAT/CLAMS: its use in detecting early childhood cognitive impairment
.
Pediatr Neurol
.
2000
;
23
(
3
):
208
15
.
17.
Morris
EE
,
Miller
NC
,
Haapala
JL
,
Georgieff
MK
,
Ramel
SE
.
Preterm infant body composition, working memory, and temperament
.
Infant Behav Dev
.
2023
;
70
:
101808
.
18.
Gotardo
JW
,
Volkmer
Nd FV
,
Stangler
GP
,
Dornelles
AD
,
Bohrer
BBd A
,
Carvalho
CG
.
Impact of peri-intraventricular haemorrhage and periventricular leukomalacia in the neurodevelopment of preterms: a systematic review and meta-analysis
.
PLoS One
.
2019
;
14
(
10
):
e0223427
.
19.
Malavolti
AM
,
Bassler
D
,
Arlettaz-Mieth
R
,
Faldella
G
,
Latal
B
,
Natalucci
G
.
Bronchopulmonary dysplasia-impact of severity and timing of diagnosis on neurodevelopment of preterm infants: a retrospective cohort study
.
BMJ Paediatr Open
.
2018
;
2
(
1
):
e000165
.
20.
Stoll
BJ
,
Hansen
NI
,
Adams-Chapman
I
,
Fanaroff
AA
,
Hintz
SR
,
Vohr
B
.
Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection
.
JAMA
.
2004
;
292
(
19
):
2357
65
.
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