..., gonadotrope cells differentiate in a stepwise process, involving both morphogenic cues and transcription factors, which drives specification of progenitor cells into specialised endocrine cells. It is crucial to understand the mechanisms underlying gonadotrope differentiation, as developmental defects...

... in both tissues. Transcription factors known to regulate Gnrhr promoter activity such as the LIM homeodomain factors LHX3 and ISL1 were also detected in the retina. Furthermore, transient transfection studies in CHO and gonadotrope cells revealed that OTX2, a major transcription factor in both pineal...

..., and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized...

... for known adenohypophysial hormones, the transcription factors Pit-1 and SF-1, cytokeratins and S-100 protein. Ten age- and sex-matched fetuses with no endocrine abnormality were controls. At 17-18 weeks of gestation, pituitaries of 4 anencephalics had no posterior lobe; the number and size of cells...

...Silvia González-Parra; Julie A. Chowen; Miguel García-Segura; Jesús Argente Pituitary transcription factor-1 (Pit-1 or GHF-1) is a transcription factor specific to the anterior pituitary and is involved in the expression and regulation of the growth hormone (GH), prolactin (PRL) and thyroid...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Transcription factors Molecular neuroendocrinology Neuroimmune interactions [M§yp§) endocrinology Molecular Neuroendocrinology...

... in the dorsomedial or medial amygdaloid nuclei of either sex. These results lead towards a molecular explanation of sex differences in female reproductive behavior by revealing an estrogen-dependent up-regulation of the message for PR, a transcription factor, in a region- and sex-specific fashion. Sex differences...

... transcriptional regulation. The functionality of this 1.2-kb fragment in driving expression of a reporter gene and its response to GnRH was shown in gonadotropes, while the overexpression of AP-1 factors, Sf-1, estrogen receptor or Smad1 revealed that the promoter is responsive to these transcription factors. Our...

... therapeutics. Gonadal steroids Gonadal steroid receptors Transcription factors Nitric oxide Gonadotropins Gonadotropin-releasing hormone 20 8 2004 © 2004 S. Karger AG, Basel 2004 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...

... demonstrated that GT1–7 nuclear proteins bind specifically to this region of the GnRH enhancer to form 4 complexes. EMSA antibody supershift analysis indicates that the transcription factors COUP-TFI and C/EBP beta bind two specific complexes, but RORα, Oct-1, Pbx-1, c-fos, or c-jun antibodies failed...

... Paraventricular nucleus Supraoptic nucleus Transgenes Homologous recombination Transcription factors Molecular neuroendocrinology Studies of the mechanisms that are responsible for cell-specific gene expression of OT and VP in the MCNs of the HNS have been limited by the absence of relevant...

...Cynthia G. Goodyer; Jacques J. Tremblay; François W. Paradis; Alexandre Marcil; Christian Lanctôt; Yves Gauthier; Jacques Drouin During early mouse embryogenesis, Pitx1 (pituitary homeobox 1), a member of the bicoid subgroup of paired homeobox-containing transcription factors, marks the stomodeum...

... synthesis, but the signal transduction pathways that coordinate these two processes are still poorly understood. Several transcription factors have been suggested to be intermediates in this process, but their expression is often transient in spite of continued VP synthesis. Transcription factor expression...

...Jacques J. Tremblay; Cynthia G. Goodyer; Jacques Drouin The Ptx (Pitx) family of homeobox transcription factors comprises Ptx1, Ptx2 and Ptx3. Ptx1 and Ptx2 are expressed in the stomodeum and its derivatives including the pituitary, as well as in mesodermal derivatives, whereas Ptx3 is expressed...

... of transcription) pathway of signal transduction. Recent evidence suggests that primarily the transcription factor STAT3 mediates leptin’s action in the hypothalamus. We have investigated the presence and cellular localization of STAT3 protein in the rat hypothalamus by means of indirect immunofluorescence...