...Zhaofei Wu; Arturo Hernandez Introduction: The actions of thyroid hormones (THs) in the central nervous system are relevant to food intake and energy expenditure. TH receptors exhibit high expression in brain areas modulating energy balance, including the arcuate, paraventricular (PVN), supraoptic...

...Zoltán Serfőző; Jan de Vente; Károly Elekes Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS...

...Samita Kundu; Angshuman Biswas; Sumedha Roy; Jhuma De; Mitali Pramanik; Arun K. Ray Background: Imbalance in thyroid hormone concentrations has been linked with profound neurobehavioral alterations in the adult. Peripheral hypothyroidism is associated with a phenomenon of central thyroid hormone...

... kindling. Since thyroid hormone regulates TRH mRNA in the paraventricular nucleus of the hypothalamus (PVN), we investigated whether basal or kindling-induced TRH mRNA expression in limbic regions is also regulated by thyroid hormone. Hypo- and hyperthyroid-ism was induced by treating rats with 0.05% 6-n...

... Thyroid hormone Insulin-like growth factor-1 Caprylic acid Histone H4 © 1992 S. Karger AG, Basel 1993 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means...

... brain regions, thyroxine replacement for 7 or 28 days caused radioligand binding to recover to control levels. Thus it appears that a neuromodulatory link between thyroid hormone and the noradrenergic system exists in many regions of the rat brain. © 1994 S. Karger AG, Basel 1994 Copyright / Drug...

...Morteza Behnam-Rassoli; Linda C. Herbert; Vyvyan Howard; Peter O.D. Pharoah; Martin Stanisstreet The effects of a pre- and postnatal hypothyroid environment on the development of the neocortex have been determined. Rats were treated with propylthiouracil (PTU) with or without thyroid hormone...

... in the anterior pituitary (AP) and hypothalamus and the expression of GAL mRNA has been shown to be modulated by peripheral gonadal steroid hormones. In view of possible interactions between members of the steroid/thyroid hormone receptor family and recent data suggesting an effect of GAL on thyrotropin secretion...

...Terry Taylor; Peter Gyves; Marc Burgunder The changing roles of the hypothalamus and pituitary in regulating thyroid hormone levels in the rat during ontogeny has not been fully elucidated. It has been reported that endogenous TRH begins to stimulate TSH secretion at 5–8 days after birth...

..., instructions or products referred to in the content or advertisements. Thyroid hormone Congenital hypothyroidism hyt/hyt hypothyroid mouse TSH Neuroendocrinology I989;49: 509-519 Evaluation and Characterization of the hyt/hyt Hypothyroid Mouse II. Abnormalities of TSH and the Thyroid Gland S m a rt...

... congenital hypothyroidism. The hyt/hyt mouse provided an ideal model for exploring the effect of severe primary inherited hypothyroidism related to deficient autonomous fetal thyroid function and was consistent with the hypothesis that thyroid hormone deficit in utero and in the early neonatal period...

...Michael M. Kaplan There is extensive deiodinative metabolism of thyroxine (T4) in thyroid hormone target organs, including the pituitary and brain. In both rat and man, most of the 3,3’,5-triiodothyronine (T3) in the body is produced outside the thyroid gland by deiodination of T4. T3...

... in similarly treated animals given thyroxine (T 4 ). Plasma B levels were not significantly different in sham-operated, TPTx, or 6MTU-treated animals. T 4 elevated plasma B in sham-operated and TPTx animals, but had no effect in animals treated with 6MTU. These data suggest that thyroid hormone is necessary...

... response was examined in the normal, adrenalectomized, thyro­ Thyroid hormone parathyroidectomized, and adrenalectomizcd-thyroparathyroid- Parathyroid hormone cctomizcd rat to determine the effects o f the absence of corti­ Stress costerone (B) and of the thyroid and parathyroid glands on this response. GH...

.... Kiss1 Kisspeptin Neuropeptide Y Galanin-like peptide Proopiomelanocortin Metabolism Reproduction Neuropeptide Arcuate nucleus Leptin Insulin Thyroid hormone Adiponectin Species viability is predicated on reproductive success. For individual animals, the caloric demands...

...Samita Kundu; Sumedha Roy; Jhuma De; Angshuman Biswas; Mitali Pramanik; Arun K. Ray During adult-onset peripheral hypothyroidism, the brain maintains normal levels of thyroid hormone for some time through a mechanism of ‘central homeostasis’. Although onset, duration, and termination...

... hormone Growth hormone-releasing hormone receptor MtT/E cells MtT/S cells Thyroid hormone Retinoic acid Thyroid hormone receptors Fig. 5 Time course study of the effects of thyroid hormone on the promoter activities of the rat GH and GHRH-receptor genes in MtT/E ( a ) and MtT/S ( b ) cells...

... that the galanin expression is severely attenuated in some neurons in adult hypothyroidism. In order to further investigate the role of thyroid hormone for the in vivo regulation of galanin gene expression, we have studied the effect of intraventricular administration of colchicine on prepro-galanin (ppGAL) mRNA...