... that explore the effects of thyroid status modulation on other hormonal axes remain scarce. We aimed to determine the effects of thyroid status modulation on prolactin, IGF-1, cortisol, LH, testosterone, and SHBG levels. We also explored whether effects differed depending on type of challenge, sex...

... from parental behavior. Testosterone could promote aggression and inhibit biparental behavior and vasopressin (AVP) could promote aggression. Given levels of aggression and parental care are closely associated with levels of empathy, we hypothesized that testosterone may influence empathetic behavior...

... Age Cognition Hippocampus Novel object test Prostate cancer Testosterone NIH Cognitive impairment associated with androgen deprivation therapy (ADT) for the treatment of prostate cancer has been shown to be long-lasting and to significantly disrupt the quality of life...

... databases including PubMed, Google Scholar, and ProQuest. Articles were included if they were original research from peer-reviewed academic journals that dealt with glutamate, estrogen, progesterone, testosterone, neurosteroids, glutamate and sex hormone interactions, or the potential impact of glutamate...

..., the effects of testosterone signaling on the NVU in males are still poorly studied. The aim of this review was to summarize and discuss the literature, providing insights and contradictions to highlight hypothesis and the need for further investigations. In the CNS, cells require a stable microenvironment...

... of episodic luteinizing hormone (LH) release. The resultant LH hypersecretion, likely the product of accelerated episodic release of gonadotropin-releasing hormone (GnRH) from the median eminence of the hypothalamus, hyperstimulates ovarian theca cell steroidogenesis, enabling testosterone (T...

...Ali Abbara; Shakunthala Narayanaswamy; Chioma Izzi-Engbeaya; Alexander N. Comninos; Sophie A. Clarke; Zainab Malik; Deborah Papadopoulou; Ailish Clobentz; Zubair Sarang; Paul Bassett; Channa N. Jayasena; Waljit S. Dhillo Background: Male testosterone levels decline by 1% per year from the age of 40...

...Kristie Conde; Carolina Fabelo; William C. Krause; Robert Propst; Jordan Goethel; Daniel Fischer; Jin Hur; Cecilia Meza; Holly A. Ingraham; Edward J. Wagner Testosterone exerts profound effects on reproduction and energy homeostasis. Like other orexigenic hormones, it increases endocannabinoid tone...

...Silvia Giatti; Benedetta Foglio; Simone Romano; Marzia Pesaresi; Giancarlo Panzica; Luis Miguel Garcia-Segura; Donatella Caruso; Roberto Cosimo Melcangi The enzymatic conversion of progesterone and testosterone by the enzyme 5alpha-reductase exerts a crucial role in the control of nervous function...

... of the peptide from the original 54 amino acids to 10 amino acids or less and by substituting key amino acid residues. Also, 2 investigational kisspeptin agonist analogs have been evaluated in clinical studies in men; in agreement with animal studies, abrupt elevations in gonadotropin and testosterone levels...

...Michael F. La Fountaine; Jill M. Wecht; Christopher M. Cirnigliaro; Steven C. Kirshblum; Ann M. Spungen; William A. Bauman Aim: To determine the effect of a 12-month intent-to-treat testosterone (T) replacement therapy (TRT) trial on QTa interval variability (QTaVI) in hypogonadal (HG) men...

... exposure on subsequent injury induced by middle cerebral artery occlusion in adulthood in male rats were examined. Rats were administered vehicle (oil), testosterone propionate (TP) or the non-aromatizable androgen dihydrotestosterone (DHT) for 5 days after birth. At 3 months of age, a focal stroke...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Testosterone Hypothalamic-pituitary-gonadal axis Hypothalamic-pituitary-adrenal axis Estrogen National Institutes of Health (NIH) 10.13039/100000002...

... to the development of metabolic disorders and obesity [ 63,64,65,66 ] and interferes with the maintenance of bone mass [ 67,68 ]. Another hormone that shows a pronounced 24-hour rhythm in both men [ 69,70,71 ] and adult male rhesus macaques [ 72,73,74 ] is testosterone. Like leptin, the plasma testosterone...

..., but not the hypogonadal. Conclusion: Hypogonadism in SCI appears to adversely affect temporal VR characteristics independently of QTc. QT/RR coherence suggests an autonomic synergism with testosterone. These findings may represent a pathologic sequelae that precedes the well-documented hypogonadic effects on QTc. 24...

... these factors with modulation of GnRH neurons have yet to be identified. Kisspeptins play a central role in the modulation of GnRH secretion and, thus, downstream regulation of gonadotropins and testosterone secretion in men. Inactivating mutations of the kisspeptin receptor have been shown to cause...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 5-Hydroxytryptophan L -DOPA RFamide-related peptide-3 Gonadotropin-inhibitory hormone Testosterone Reproduction Mice...

...Nicola Pluchino; Filippo Ninni; Elena Casarosa; Andrea Giannini; Sara Merlini; Alessandra Cubeddu; Michele Luisi; Vito Cela; Andrea Riccardo Genazzani Aims: The present study aims at evaluating the effect of a 2-week treatment with testosterone (T), dihydrotestosterone (DHT) and estradiol valerate...

.... After an overnight fast, blood samples were collected for measurements of ghrelin, testosterone, bioavailable testosterone (BT) and estradiol. Statistical analysis was performed with adjustments for age and body mass index. Results are given as mean ± standard deviation. Results: Ghrelin levels were...

...Patricia Boksa; Ying Zhang Background/Aims: Global birth hypoxia in rats has been shown to produce long-term changes in central nervous system functions, known to be influenced by neonatal testosterone secretion. Birth hypoxia alters levels of several circulating hormones, but it is unknown...