... and pathology parameters. Method: Tumor-bearing mice with different positive rates of somatostatin receptor II (SSTR2) were established with HEK293-SSTR2 and HEK293 cells, and imaging was performed on the same mouse with [ 68 Ga]Ga-DOTA-TATE, [ 68 Ga]Ga-DOTA-JR11, and [ 18 F]AlF-NOTA-JR11 at 20, 60, and 120 min...

..., instructions or products referred to in the content or advertisements. Carcinoid tumours Gastroenteropancreatic neuroendocrine tumours Neuroendocrine tumour Somatostatin receptor Conference Report Neuroendocrinology 2019;108:45 53 DOI: 10.1159/000493767 Received: July 1, 2018 Accepted after...

...Meike Körner; Beatrice Waser; Emanuel Christ; Jürgen Beck; Jean Claude Reubi Background: Somatostatin receptor (sst) overexpression in neuroendocrine tumors allows sst-targeted tumor imaging and therapy with long-acting, cold, or radioactive somatostatin analogs. sst2 has been most important, owing...

...Sanne E. Franck; Federico Gatto; Aart Jan van der Lely; Joseph A.M.J.L. Janssen; Alof H.G. Dallenga; A. Paul Nagtegaal; Leo J. Hofland; Sebastian J.C.M.M. Neggers Background: Growth hormone-secreting pituitary adenomas (somatotroph adenoma) predominantly express somatostatin receptors (SSTRs...

... neuroendocrine tumour of the skin. It has been speculated that MCCs express somatostatin receptors (SSTRs), but this has never been assessed in a large series of MCCs. The main aim of this study was to assess the expression of SSTR2A and SSTR5 in MCC tumours. The secondary aims were to assess whether expression...

... and/or distant metastases (N+ and/or M+). Somatostatin receptor Gastric inhibitory peptide receptor Neuroendocrine tumor MIB-1 proliferation index Receptor autoradiography Gut and extraintestinal neuroendocrine neoplasms (NEN) represent challenging tumors in terms of clinical management...

...Amelie Lupp; Falko Nagel; Christian Doll; Christoph Röcken; Matthias Evert; Christian Mawrin; Wolfgang Saeger; Stefan Schulz Background: Among the five somatostatin receptors (sst 1 -sst 5 ), the sst 3 receptor displays a distinct pharmacological profile. Like sst 2 , the sst 3 receptor efficiently...

...Amelie Lupp; Anna Hunder; Aline Petrich; Falko Nagel; Christian Doll; Stefan Schulz Objective: The frequent overexpression of somatostatin receptors (sst) in neuroendocrine tumors provides the molecular basis for the diagnostic and therapeutic application of stable somatostatin analogs. Whereas...

... release by cultured rat pituitary cells. Neuroendocrinology 1989;50:44–50. 6. Shimon I, Taylor JE, Dong JZ, Bitonte RA, Kim S, Morgan B, Coy DH, Culler MD, Melmed S: Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of sstr2 and sstr5 for growth hormone...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Somatostatin receptor Well-differentiated tumours Somatostatin analogues Survival rate Metastases and/or vascular/neural involvement may...

... analogues for neuroblastoma therapy or/and scintigraphy. Somatostatin receptor Receptor Neuroblastoma Clinical neuroendocrinology 28 10 1994 6 10 1995 9 4 2008 © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... synthesized peptide – is suggested. We have investigated the ontogeny and possible circadian and circannual variations of somatostatin and somatostatin receptor gene expression in the rat pineal gland using RT-PCR. Somatostatin gene expression was observed in the pineal of animals up to 15 days of postnatal...

... remains to be identified and suggests that SRIH controls other hypothalamic functions at this level. Arcuate nucleus Growth hormone-releasing hormone Somatostatin receptor Radioautography Hybridization, in situ Jérôme Bertherat Pascal Dournaud Anne Bérodh Elisabeth Normandc Bertrand Blochc...

... SRIF a agonists which could be key ligands for studying interactions at the SRIF a receptor as well as being useful selective therapeutic agents 11 08 1986 25 11 1986 2 4 2008 Somatostatin receptor Adenohypophysis Cerebral cortex Selective agonist Binding Original Papers...

...Lars Stelter; Holger Amthauer; Annett Rexin; Jens Pinkernelle; Petra Schulz; Roger Michel; Timm Denecke; Heiner Stiepani; Bernd Hamm; Bertram Wiedenmann; Arne Scholz Somatostatin receptor (SSTR) scintigraphy is currently used as one standard imaging modality in neuroendocrine tumors (NETs). However...

...Luis Fabián Canosa; Xinwei Lin; Richard E. Peter In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both...

... the effects of thyroid hormones on TSH secretion may be mediated in part through alterations in the gene expression of pituitary somatostatin receptors (SSTR), 3-week-old male Sprague-Dawley rats were rendered hypothyroid with antithyroid drugs for 3 weeks. Total RNA extracted from anterior pituitaries were...