... to in the content or advertisements. Somatostatin-dopamine chimera Somatostatin analogs Medullary thyroid cancer Apoptosis Migration Zebrafish Neuroendocrine neoplasms (NENs) represent a heterogeneous group of tumors that account for about 0.5% of all newly diagnosed malignancies. The age...

... of somatostatin analogs (SSAs) are increasingly utilized in the management of inoperable/metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs), progressing on standard 4-weekly regimens. Objective: To evaluate the antiproliferative effect of 3-weekly SSA administration in a retrospective GEP-NET...

... Conference participants Systemic therapies established in the management of patients with neuroendocrine tumors (NETs) include somatostatin analogs and interferon-α, also referred to as biotherapy. Recent randomized controlled studies have extended the knowledge on the frequency of side effects associated...

...Anja Rinke; Michael Wittenberg; Carmen Schade-Brittinger; Behnaz Aminossadati; Erdmuthe Ronicke; Thomas M. Gress; Hans-Helge Müller; Rudolf Arnold; for the PROMID Study Group Background: Somatostatin analogs have been shown to control the growth of well-differentiated metastatic neuroendocrine...

... with that in human GEP-NETs to evaluate the usefulness of these cells as a model for studying the IGF system in GEP-NETs, (2) determine whether panNET cells produce growth factors that activate IR-A, and (3) investigate whether somatostatin analogs (SSAs) and/or dopamine agonists (DAs) influence the production...

... hypersecretion, medical treatment with dopamine agonists (DAs; particularly cabergoline) or somatostatin analogs (SAs) can be used. The GH receptor antagonist pegvisomant is helpful in patients who are totally or partially resistant to SAs and can be given in association with both SAs and/or DAs. Thanks...

... options are limited. A relatively new therapeutic modality, peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs, is currently available in a number of mostly European centers. Complete and partial responses obtained after treatment with [ 90 Y-DOTA⁰,Tyr 3 ]octreotide...

...Raquel S. Jallad; Marcello D. Bronstein Background: Previous data indicate a beneficial effect of cabergoline (CAB) association to somatostatin analogs (SA) in acromegalics resistant to SA monotherapy. Objective: To assess the efficacy of CAB association on acromegalics with high IGF-I on stable...

..., instructions or products referred to in the content or advertisements. Somatostatin secretion Somatostatin analogs Cultured hypothalamus cells Neuroendocrinology 39: 397-402 (1984) Somatostatin Analogs Inhibit Somatostatin Secretion from Cultured Hypothalamus Cells Roben A. Peterfreund. Wylie W...

...Simona Grozinsky-Glasberg; Giulia Franchi; Mabel Teng; Chrysanthia A. Leontiou; Antônio Ribeiro de Oliveira Jr.; Paolo Dalino; Nabila Salahuddin; Márta Korbonits; Ashley B. Grossman Background/Aim: The mode of action of the somatostatin analog octreotide on neuro-endocrine tumour proliferation...

.... Endocrine tumors Carcinoid tumors Ileum Octreotide Carcinoid syndrome Liver metastases Somatostatin analogs Statistical analyses were carried out using SPSS version 13 for Windows, and the statistical significance was set at two-tailed p values less than 0.05. Of the 59 patients enrolled, 49...

... with somatostatin analogs. Recently, long-acting somatostatin analog depot formulations, octreotide LAR and lanreotide SR have become available. Somatostatin analogs control GH/insulin-like growth factor (IGF)-1 excess, induce tumor shrinkage in a high proportion of patients, improve symptoms of acromegaly...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Carcinoid syndrome Somatostatin analogs Magnetic resonance imaging Liver Octreotide Neuroendocrine tumors Clinical...

..., instructions or products referred to in the content or advertisements. Somatostatin Somatostatin receptors Somatostatin analogs Acromegaly Growth hormone Insulin-like growth factors Clinical neuroendocrinology Acromegaly is a chronic disorder characterized by excessive growth hormone (GH...

... somatotrophe pituitary adenomas GH secretion is controlled by both SSTR2 and SSTR5. However, in clinical practice only somatostatin analogs selective for SSTR2 (octreotide and lanreotide) are available. This may explain why clinical and in vitro responses to these analogs in acromegaly are only partial...