... have tried to elucidate how this cycle, or this hormone, affects the plasticity of inhibitory networks and the structure of interneurons. Among these cells, somatostatin-expressing O-LM neurons of the hippocampus are especially interesting. They have a role in the modulation of theta oscillations...

...: Pituitary neuroendocrine tumors (PitNETs) represent approximately 15% of all intracranial tumors and usually are associated with severe comorbidities. Unfortunately, a relevant number of patients do not respond to currently available pharmacological treatments, that is, somatostatin analogs (SSAs...

...Iben Engelund Luna; Nina Monrad; Tina Binderup; Christina Boisen Thoegersen; Linda Hilsted; Claus Jensen; Birgitte Federspiel; Ulrich Knigge Background/Objective: Neuroendocrine neoplasms of the pancreas and duodenum with predominant or exclusive immunoreactivity for somatostatin (pdSOMs) are rare...

...Amelie Lupp; Falko Nagel; Christian Doll; Christoph Röcken; Matthias Evert; Christian Mawrin; Wolfgang Saeger; Stefan Schulz Background: Among the five somatostatin receptors (sst 1 -sst 5 ), the sst 3 receptor displays a distinct pharmacological profile. Like sst 2 , the sst 3 receptor efficiently...

.../growth hormone (GH) secretion, but direct evidence for the effectiveness of GHRH antagonists on human pituitary tissue is still lacking. In this study, we investigated the inhibitory effect of our GHRH antagonists MZ-4-71 and JV-1-36 and the somatostatin (SST) analog RC-160 on superfused pituitary cells...

...Pietro Ameri; Diego Ferone During the last two decades, research into the modulation of immunity by the neuroendocrine system has flourished, unravelling significant effects of several neuropeptides, including somatostatin (SRIH), and especially cortistatin (CST), on immune cells. Scientists have...

...Amelie Lupp; Anna Hunder; Aline Petrich; Falko Nagel; Christian Doll; Stefan Schulz Objective: The frequent overexpression of somatostatin receptors (sst) in neuroendocrine tumors provides the molecular basis for the diagnostic and therapeutic application of stable somatostatin analogs. Whereas...

...Thomas Walter; Juliette Hommell-Fontaine; Géraldine Gouysse; Céline Pourreyron; Mimoun Nejjari; Karine Villaume; Sylvain Causeret; Valérie Hervieu; Gilles Poncet; Colette Roche; Jean-Yves Scoazec Background/Aims: Experimental studies in vitro suggest that somatostatin and some of its analogues used...

... was conducted to elucidate the relationship between GH pulses and neuropeptide levels in the cerebrospinal fluid (CSF) of the third ventricle in ovariectomized goats. Methods: CSF and plasma samples were collected every 15 min. Levels of plasma GH and profiles of GH-releasing hormone (GHRH), somatostatin (SRIH...

...Raquel S. Jallad; Marcello D. Bronstein Background: Previous data indicate a beneficial effect of cabergoline (CAB) association to somatostatin analogs (SA) in acromegalics resistant to SA monotherapy. Objective: To assess the efficacy of CAB association on acromegalics with high IGF-I on stable...

... obtained reveal that sulfadiazine partially prevents the decrease in somatostatin (SRIH)-like immunoreactivity content in the temporal cortex of rats infused with Aβ(25–35) during 14 days. In addition, sulfadiazine blocks the Aβ(25–35)-induced reduction in the SRIH receptor density and in SRIH receptor...

... pituitary cells in response to GH-releasing hormone (GHRH) in the presence of somatostatin (SS)-28. Dispersed pituitary cells from 6- and 24-month-old rats fed ad libitum (AL-Y, AL-O, respectively) and 24-month-old rats dietary restricted from 6 weeks of age (DR-O) were subjected to a reverse hemolytic...

...Suzanne L. Dickson; Odile Viltart; Alex R.T. Bailey; Gareth Leng We set out to determine whether the central action of growth hormone (GH) secretagogues to induce Fos protein expression in the arcuate nucleus is influenced by central somatostatin action. Conscious male rats were injected i.v...

...Karen S.L. Lam; Gopesh Srivastava Supraphysiological doses of glucocorticoids inhibit growth hormone (GH) secretion in man and experimental animals. We investigated whether glucocorticoids inhibit GH secretion through changes in the gene expression of GH, hypothalamic somatostatin (SS) and GH...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth hormone-releasing peptides Somatostatin Growth hormone Sleep Aging Clinical neuroendocrinology IMs(mn...

...Eugenia Mato; Pilar Santisteban; Julie A. Chowen; Oscar Fornas; Martijn Bouwens; Manel Puig-Domingo; Jesús Argente; Susan M. Webb The origin of somatostatin in the pineal gland is controversial as a double origin – neural in pinealopetal nerve fibers and parenchymal corresponding to locally...

... by which hexarelin and GHRP-6, two GH-releasing peptides, mediate their actions. Although previous studies have looked at the role of growth hormone-releasing hormone (GHRH) and somatostatin in regulating the action of GHRP-6 in culture and in stressed animals, our study looked at the role of both...

... the interaction of the maximally effective intravenous dose of hexarelin (2 µg/kg i.v.) with GH-releasing hormone (GHRH, 2 µg/kg i.v.) and somatostatin (2 µg/kg/h i.v.). In a second experiment involving another 6 male subjects, we evaluated the interaction of hexarelin with neuroactive substances...

... suggested that GC exert an inhibitory role in the hypothalamus surpassing the GC-positive effect at the somatotrope level. To test the hypothesis that GC can affect growth hormone-releasing factor (GRF) and somatostatin (SS) at the hypothalamic level, we studied the effect of corticosterone...

...Rob J. Lieverse; Jan B.M.J. Jansen; Ad A.M. Masclee; Cornells B.H.W. Lamers Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstated to decrease food intake. We investigated, in a randomized double-blind investigation in 10...