..., sleep, and arousal is unclear. We previously identified and characterized Nts neurons in the zebrafish hypothalamus. Materials and Methods: In order to study the role of Nts, nts mutant ( nts –/–), and overexpressing zebrafish were generated. Results: The expression of both nts mRNA and Nts protein...

... area) also play a role in the regulation of the sleep/wake cycle and may explain the comorbidity of eating and sleep disorders observed in AD patients. Inadequate sleep increases the neurodegenerative process, for example, the decrease of slow-wave sleep impairs clearance of β-amyloid peptide (Aβ...

...Christine Lu; Eleanor G. Hutchens; Leon S. Farhy; Heather G. Bonner; Paul M. Suratt; Christopher R. McCartney Objective: During the early follicular phase, sleep-related luteinizing hormone (LH) pulse initiation is positively associated with brief awakenings but negatively associated with rapid eye...

... a combination of sleep logs and wrist-worn actigraphs (Actiwatch 2, Philips-Respironics, Bend, Oreg., USA), ambulatory sleep/wake patterns were recorded in all participants for 2 weeks. Actigraphs record 3-dimensional arm movement, which is useful for determining gross patterns of sleep and wake [ 17...

...Elisabetta Verrillo; Carla Bizzarri; Marco Cappa; Oliviero Bruni; Martino Pavone; Raffaele Ferri; Renato Cutrera Background/Aims: Growth hormone (GH) is preferentially secreted during slow wave sleep and the interactions between human sleep and the somatotropic system are well documented, although...

... is restricted to a few neurone populations, many of which are involved in the sleep-wake cycle, circadian regulation or food regulation. In the forebrain we found intense Ngb expression in neurones in the piriform cortex, the central and medial amygdala, the medial preoptic area, the suprachiasmatic nucleus...

...Theodore C. Friedman; Diego García-Borreguero; Donna Hardwick; Cecilia N. Akuete; John L. Doppman; Lorah D. Dorn; Charles N. Barker; Jack A. Yanovski; George P. Chrousos To evaluate the sleep disturbances of patients with Cushing syndrome and to examine the relationship between the sleep...

...F. Obál, Jr.; J. Fang; L.C. Payne; J.M. Krueger The involvement of endogenous growth-hormone-releasing hormone (GHRH) in the sleep-promoting activity of interleukin-1 (IL1) was studied. The effects on sleep of intracerebro ventricular injection of IL1 were tested in rats pretreated...

... administration of GHRH in normal men results in increased slow-wave sleep (SWS) and blunted cortisol levels. The effect of GHRP on nocturnal hormone secretion and on the sleep electroencephalogram (EEG) is still unknown. We compared the effect of repetitive i.v. boluses (4 × 50 µg) of GHRP and placebo (PL...

...Manny W. Radomski; Alain Buguet; Félix Doua; Pascal Bogui; Philippe Tapie Human African trypanosomiasis (sleeping sickness) is a unique disease model of disrupted circadian rhythms in the sleep-wake cycle and cortisol and prolactin secretion. This study examined the temporal relationship between...

...Janet Mullington; Dirk Hermann; Florian Holsboer; Thomas Pollmächer Although the major daily peak in plasma growth hormone (GH) level normally occurs during the early part of nocturnal sleep, it is known that in about one quarter of young healthy men, peaks in circulating human GH occur before...

..., 1 µg adrenocorticotropic hormone (ACTH), or placebo to simulate pulsatile hormone secretion. Plasma melatonin and cortisol responses during the treatment and nocturnal sleep electroencephalograms after the treatment were recorded. Administration of CRH reduced melatonin secretion significantly below...

...Ernst Späth-Schwalbe; Dirk Uthgenannt; Nils Körting; Horst-Lorenz Fehm; Jan Born The secretory activity of the pituitary-adrenocortical axis at night is characterized by a quiescent period during the first hours of sleep, preceding a period of enhanced activity in the early morning hours...

...Georges Copinschi; Rachel Leproult; Anne Van Onderbergen; Anne Caufriez; Katrina Y. Cole; Lisa M. Schilling; Carl M. Mendel; Inge De Lepeleire; James A. Bolognese; Eve Van Cauter Previous studies have indicated the existence of common mechanisms regulating sleep and somatotropic activity...

...Ferenc Obál, Jr.; Balazs Bodosi; Annamaria Szilágyi; Balint Kacsóh; James M. Krueger To determine whether an acute withdrawal of growth hormone (GH) alters sleep, the effects of antiserum to GH (GH-AS) on sleep were studied in the rat. Sleep-wake activity and cortical brain temperature (Tc) were...

... occasions in random order: during daytime between 10.00 and 14.00 h (‘day’ studies), at night between 22.00 and 02.00 h, when the women were awake (‘night’ studies), and finally, during the identical night hours, when the women were asleep (‘sleep’ studies). On all occasions, blood was collected at 10-min...

... the activity of the HPA axis in these animals. We tested the influence of potassium cancrenoate, a selective MR antagonist, on basal cortisol secretion in 10 healthy young men during sleep. Cortisol, ACTH, vasopressin and growth hormone (GH) were determined at 22.00, 23.00, 01.00, 04.00 and 07.00 h. Sleep...

...Lorenz Fehm; Jens Clausing; Werner Kern; Reinhard Pietrowsky; Jan Born We reinvestigated the temporal relationship between sleep and LH secretion in healthy adult males by comparing LH secretion patterns during sleep with those during the 6 h of wakefulness preceding the sleep epoch. Sleep stages...

...Christina Åström; Leif Christensen; Flemming Gjerris; Werner Trojaborg Daytime somnolence and fatigue are frequently ignored symptoms in acromegaly. To examine whether sleep apnea or other abnormalities in the sleep structure is the underlying cause, 9 young patients with active untreated...

...Christin Åström; Jörgen Lindholm The sleep in young adults with severe isolated growth hormone deficiency (IGHD) was examined by polysomnography. There was a significant decrease in delta sleep time (= stages 3 + 4, slow wave sleep, ‘deep sleep’), especially in stage 4. The total sleep time...