... with respect to peptide receptor radionuclide therapy (PRRT). This comprehensive review evaluates the data supporting approved therapies for GEP-NETs and recommendations for therapeutic sequencing with a focus on how PRRT currently fits within sequencing algorithms. The current recommendations for PRRT...

...Matthew L. Romo; C. Mary Schooling Background: Observational evidence regarding the role of leptin in Alzheimer disease (AD) is conflicting. We sought to determine the causal role of circulating leptin and soluble plasma leptin receptor (sOB-R) levels in AD using a separate-sample Mendelian...

... increases during both the initiation of normal puberty and after hypothalamic lesions that induce sexual precocity. Since blockade of epidermal growth factor receptors (EGFR), which mediate TGFα actions, delayed the normal timing of puberty, it was postulated that TGFα/EGFR contributes to the neuroendocrine...

...Anderson On-Lam Wong; Glen van der Kraak; John Philip Chang Previously, we have demonstrated that dopamine (DA) stimulates growth hormone (GH) release from the goldfish pituitary through DA D1 receptors. In the present study, the role of cAMP in DA D1-stimulated GH release was investigated using...

...Florence Rage; Catherine Rougeot; Lucia Tapia-Arancibia GABA A receptors mediate the inhibition of somatostatin gene expression and NMDA receptors mediate its stimulation. The aim of this study was to determine whether the two major neurotransmitters in the central nervous system (GABA...

... with dexamethasone (DEX, 40 µg/kg) markedly inhibited M . fermentans -induced depletion of ME CRH-41 and the increase in serum ACTH and CS. Injection of the type II corticosteroid receptor antagonist RU-38486, but not the type 1 antagonist RU-28318, enhanced the adrenocortical response and completely abolished...

...M.K. Agarwal; F. Mirshahi; M. Mirshahi; W. Rostene The mineralocorticoid receptor (MCR) in the brain of adult male rats was analyzed with the aid of an antiserum generated by immunizing rabbits with this protein purified biochemically from rat kidney. In Western blots, the antibody recognized...

... of melatonin binding sites in the brain of the salmon, Salmo salar . Brains were collected for receptor binding assay and autoradiography at each of three time points: just after lights on, just before lights off, and in the dark at midnight (photoperiod light-dark 12:12, lights on at 08.00 h, lights off...

...Aaron Lawson; Rexford S. Ahima; Zygmunt Krozowski; Richard E. Harlan The postnatal development of corticosteroid receptor immunoreactivity in the rat cerebellum and related brainstem nuclei was studied using a type I receptor antiserum, MINREC4, and a type II receptor monoclonal antibody, BUGR2...

... binding sites for 125 I-recombinant human IL-1α have been identified in the mouse testis with characteristics similar to those of type I IL-1 receptors on T lymphocytes and fibroblasts. The present study employed in situ hybridization histochemistry with 35 S-labeled antisense cRNA probes derived from...

... in the medial preoptic area (MPOA). Since β-endorphin neurons located in the arcuate nucleus project extensively to the MPOA, we have hypothesized that the EV-induced loss of these afferents induces a compensatory upregulation of µ-opioid receptors in opioid target neurons. In order to test this hypothesis, we...

... for further studies. The hippocampus, the hypothalamus and the pituitary were among other regions containing prolactin-binding sites. In the choroid plexus the amount of PRL receptors was significantly higher in females than in males and was also found in both sexes to decrease with age. The binding affinity...

...Bojidar Stankov; Bruno Cozzi; Valeria Lucini; Pietro Fumagalli; Francesco Scaglione; Franco Fraschini Melatonin receptors were characterized in the brains of three mammals (rabbit, horse and sheep) by an in vitro binding technique, using 2-[ 125 I]iodomelatonin as labelled ligand. Although binding...

...Donatella Dondi; Roberto Maggi; Alberto E. Panerai; Flavio Piva; Patrizia Limonta The concentrations of β-endorphin have been shown to change in the rat brain during pregnancy and lactation. This study has been performed in order to analyze whether also brain opioid receptors might undergo...

...Kevin L. Grove; Vickie I. Cook; Robert C. Speth In vitro receptor autoradiography, using the radiolabeled angiotensin II (Ang II) antagonist 125 I-sar 1 , ile 8 Ang II ( ∣25 I-SI Ang II; 250 p M ) in the absence or presence of 1 µ M Ang II, was used to identify Ang II receptor binding sites...

...). Guanylate cyclase-coupled receptors (ANF-Ri) represent 30% and non-guanylate cyclase-coupled ANF receptors (ANF-R2) represent 70% of the total ANF receptors present in this tissue. To provide detailed cellular localization of the binding sites, the technique of electron-microscopic autoradiography...

...Bernadette Lutz-Bucher; Krisztina Kovacs; Gabor Makara; Ervin Stark; Bernard Koch The regulation of pituitary vasopressin (VP) receptor concentration was investigated in rats with antero-lateral cuts (ALC) placed around the hypothalamus, as well as in Brattleboro homozygotes (HO) that genetically...

..., instructions or products referred to in the content or advertisements. Aldosterone Corticosterone Receptors Salt appetite Brain Neuroendocrinology 43:38-43 (1986) Aldosterone Effects on Salt Appetite in Adrenalectomized Rats Bruce S. M c E w e n L a r e n T. Lambdin». Thomas C. Rainbowb t...

...Ronald de Kloet; Door A.M. Voorhuis; Ypie Boschma; Jack Elands Previous studies have provided evidence for a discrete localization of two types of vasopressin (AVP)-labeled binding sites in the rat brain, i.e., regions labeled preferentially with AVP (putative AVP receptors) and regions labeled...

...B.M. Lidy Verburg-Van Kemenade; Marie Christine Tonon; Bruce G. Jenks; Hubert Vaudry While mammalian dopamine receptors have been extensively characterized, very little attention has been given to these receptors in lower vertebrates. Dopamine is thought to be a physiologically important...