... of early-life stress effects on central regulation of reproduction need to be elucidated. We have investigated the effects of PWSI on function of arcuate kisspeptin (ARC KISS1 ) neurons by using electrophysiological techniques combining with monitoring of puberty onset and estrous cycle in male and female...

... growth factor-1 (IGF-1) has emerged as a prime candidate for playing an important role in the onset of puberty. This review will first present initial research demonstrating that IGF-1 increases in circulation as puberty approaches, is able to induce the release of prepubertal GnRH, and can advance...

... that need to be addressed and simultaneously point towards events causative of pubertal disturbance that could be exploited for alternative test methods. We propose 6 pAOPs that could explain the disruption of pubertal timing by interfering with the central hypothalamic trigger of puberty, GnRH neurons...

...Carlos Francisco Aylwin; Katinka Vigh-Conrad; Alejandro Lomniczi To attain sexual competence, all mammalian species go through puberty, a maturational period during which body growth and development of secondary sexual characteristics occur. Puberty begins when the diurnal pulsatile gonadotropin...

... regulating gonadotropin-releasing hormone (GnRH) secretion, and hence gonadotropin secretion, is gradually being unraveled. This has increased our understanding of the central mechanism regulating puberty and subsequent reproductive performance in mammals. Recently, emerging evidence has indicated...

.... Development Fertility Kisspeptin Mouse Neuropeptides Puberty Puberty in mammals is a complex process of sexual development which leads to complete gonadal maturation and the attainment of full reproductive capacity [ 1,2,3,4 ]. Puberty can take place gonad independently [ 5 ] with the activation...

...Felix R. Day; John R.B. Perry; Ken K. Ong Understanding the regulation of puberty timing has relevance to developmental and human biology and to the pathogenesis of various diseases. Recent large-scale genome-wide association studies on puberty timing and adult height, body mass index (BMI...

... not reach adult values until B3PH2 stage. Conclusions: The progression of female puberty includes an increase in the levels of adrenocortical and ovarian steroid secretions and a gain of adult female-like patterns of estradiol-17β secretion within their first waking hour. [email protected] 25...

...Paulina A. Rzeczkowska; Huayan Hou; Michael D. Wilson; Mark R. Palmert All reproductively competent adults have gone through puberty. While key genes and signaling pathways that lead to the onset of sexual maturation are known, the molecular mechanisms that determine when an individual enters...

... ]. In this context, the generation of Vgf -KO mice evidenced that congenital elimination of VGF peptides induce delayed puberty onset, reduced fertility, decreased ovarian and uterus weight and decreased mRNA and protein contents of LH and FSH β-subunits at the pituitary [ 7 ]. These data strongly suggested...

... to in the content or advertisements. Gonadotropin-releasing hormone neuron Astrocyte Tanycyte Preoptic area Median eminence Puberty Estrous cycle Reproductive function is centrally controlled by a group of specialized neurosecretory neurons that produce the neuropeptide gonadotropin-releasing...

..., instructions or products referred to in the content or advertisements. Gonadotropin-releasing hormone Luteinizing hormone Progesterone Puberty Female reproduction National Institutes of Health (NIH) 10.13039/100000002 Early puberty is characterized by sleep-entrained increases...

...Xiao-Bing Zhang; Daniel J. Spergel Kisspeptin plays an important role in puberty and subsequent fertility by activating its receptor, G-protein-coupled receptor 54 (GPR54), and increasing cytoplasmic free Ca 2+ concentration ([Ca 2+ ] i ) and gonadotropin-releasing hormone (GnRH) secretion in GnRH...

... to mature during puberty. The aim of the present study was to investigate whether post-weaning high-fat consumption can modify the endocrine responses of pubertal rats to an acute stress. Methods: Weaning male and female Wistar rats on postnatal day (P) 22 were fed either a high-fat (HF; 45% calories from...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Gonadotropin-releasing hormone deficiency Gonadotropin-releasing hormone neuronal ontogeny Puberty Kallmann syndrome Hypogonadotropic hypogonadism A unique neural...

...Nelly Pitteloud; Apisadaporn Thambundit; Andrew A. Dwyer; John L. Falardeau; Lacey Plummer; Lisa M. Caronia; Frances J. Hayes; Hang Lee; Paul A. Boepple; William F. Crowley, Jr. Background: The onset of sexual maturation at puberty is a unique developmental period from a neuroendocrine perspective...

... suggest that functional patterns of ER and PR expression arise upon reactivation of the hypothalamic-pituitary-gonadal axis at puberty. The degrees of receptor expression and of nuclear translocation most likely reflect peripubertal changes in the levels of gonadal steroids. Taken together, these results...

... in neurons of adults. We hypothesized, therefore, that Glu and GABA neurons which develop ER or PR expression during puberty may participate in reactivation of the hypothalamic-pituitary-gonadal axis. To identify those neurons in midpubertal female cynomolgus monkeys, we performed immunofluorescence staining...

...Ozhan Eyigor; Lothar Jennes Excitatory amino acids, particularly glutamate, are thought to be important for the maturation of the brain-pituitary-gonadal axis and the induction of puberty in the rat. We have previously shown that, in the female rat, GnRH neurons preferentially express the KA2...

.... Neuropeptide Y Gonadotropin-releasing hormone Gonadotropin-releasing hormone receptor Puberty Regulation of Gonadotropins Ncuroendocrinology 1995;61:293-300 Dominique D. Pierroz Nadine M. Gruaz Violaine d'All&ves Michel L. Auberl Division of Biology of Growth and Reproduction. Department of Pediatrics...