... alters the brain content of these steroid hormones and cholesterol, a precursor to all steroid hormones, has yet to be extensively investigated. Thus, the goal of this study was to determine whether cocaine self-administration (SA) altered the content of cholesterol and steroid hormones (progesterone...

... the contributions of hormones associated with stress and the maternal period (glucocorticoids, prolactin, estradiol/progesterone) on CRFR1 levels using a CRFR1-GFP reporter mouse line and immunohistochemistry. Results: Administration of dexamethasone, an agonist of the glucocorticoid receptor, elevated CRFR1...

... databases including PubMed, Google Scholar, and ProQuest. Articles were included if they were original research from peer-reviewed academic journals that dealt with glutamate, estrogen, progesterone, testosterone, neurosteroids, glutamate and sex hormone interactions, or the potential impact of glutamate...

...Taysa Bervian Bassani; Cynthia Silva Bartolomeo; Rafaela Brito Oliveira; Rodrigo Portes Ureshino Neuroactive steroids can be synthetic or endogenous molecules produced by neuronal and glial cells and peripheral glands. Examples include estrogens, testosterone, progesterone and its reduced...

... or VCD (160 mg/kg) for 15 days. On 56th–66th days after treatment onset, the groups to be stressed received s.c implants containing placebo (PL), 17β-estradiol (E2), progesterone (P4), or E2P4. At 80 ± 5 days after VCD/oil injections, stress was applied for 30 min. Blood samples were collected...

...Ivonne Denise Uzair; Marina Ines Flamini; Angel Matias Sanchez Background: Synaptic plasticity is the neuronal capacity to modify the function and structure of dendritic spines (DS) in response to neuromodulators. Sex steroids, particularly 17β-estradiol (E2) and progesterone (P4), are key...

...Silvia Giatti; Benedetta Foglio; Simone Romano; Marzia Pesaresi; Giancarlo Panzica; Luis Miguel Garcia-Segura; Donatella Caruso; Roberto Cosimo Melcangi The enzymatic conversion of progesterone and testosterone by the enzyme 5alpha-reductase exerts a crucial role in the control of nervous function...

...Beilei Lei; Haichen Wang; Seongtae Jeong; Justin T. Hsieh; Mohammed Majeed; Hana Dawson; Huaxin Sheng; David S. Warner; Michael L. James In models of acute brain injury, progesterone improves recovery through several mechanisms including modulation of neuroinflammation. Secondary injury from...

... for 2 years with vehicle, estradiol (E 2 ), or estradiol + progesterone (E 2 + P 4 ). While the overall cytoarchitecture of the ME underwent relatively few changes with age and hormones, changes to some features of neural and glial components near the portal capillaries were observed. Specifically...

...Justin T. Hsieh; Beilei Lei; Huaxin Sheng; Talagnair Venkatraman; Christopher D. Lascola; David S. Warner; Michael L. James Background: Preclinical evidence suggests that progesterone improves recovery after intracerebral hemorrhage (ICH); however, gonadal hormones have sex-specific effects...

... disintegration and regeneration. Inflammasomes are vital effectors in innate immunity. Their activation in brain-intrinsic immune cells contributes to ischemia-related brain damage. The steroids 17β-estradiol (E2) and progesterone (P) are neuroprotective and anti-inflammatory. Using a transient focal rat...

...Mélanie Bourque; Marc Morissette; Sara Al Sweidi; Donatella Caruso; Roberto C. Melcangi; Thérèse Di Paolo Background: Numerous studies have reported on the neuroprotective activity of estradiol, whereas the effect of the other ovarian steroid, progesterone, is much less documented. Methods...

... 2 , E 2 + progesterone, or vehicle) selected to mimic currently prescribed hormone replacement therapies used for the alleviation of menopausal symptoms in women. We found that about half of GnRH perikarya co-expressed GPER, while only about 12% of GnRH processes and terminals in the median eminence...

... differences in stress reactivity, suggesting that the fluctuations in gonadal steroid levels across the estrous cycle may play a regulatory role in the stress-induced cytokine expression. The present studies were designed to investigate the role of 17-β-estradiol (E 2 ) and progesterone (Pg) in regulating...

...Pardes Habib; Jon Dang; Alexander Slowik; Marion Victor; Cordian Beyer 17β-Estradiol (E 2 ) and progesterone (P) are neuroprotective in acute brain injury by attenuating neuropathophysiological processes and regulating local glial function. Besides controlling brain-intrinsic immune responses...

...Shaila K. Mani; Jeffrey D. Blaustein The steroid hormone, progesterone (P), modulates neuroendocrine functions in the central nervous system resulting in integration of reproduction and reproductive behaviors in female mammals. Although it is widely recognized that P’s effects on female sex...

.... Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increase in the early morning in early pubertal girls and may help slow daytime GnRH frequency. Objective: To evaluate the effect of progesterone on LH pulse frequency in early to mid-pubertal girls. Design: Controlled...

...Melisa M. Bonafede; Susana R. Valdez; Fiorella Campo Verde Arboccó; Gisela E. Pennacchio; Marta Soaje; Graciela A. Jahn Background/Aims: Progesterone (P 4 ) fall provoked by spontaneous or prostaglandin F2α (PGF2α)-induced luteolysis in late pregnant rats triggers a prolactin (PRL) surge 12–24 h...

...Rupert Lanzenberger; Markus Mitterhauser; Georg S. Kranz; Christoph Spindelegger; Wolfgang Wadsak; Patrycja Stein; Ulrike Moser; Markus Savli; Kurt Kletter; Siegfried Kasper Background: Progesterone (P) is thought to influence mood and affective states. Alterations of the inhibitory serotonin-1A (5...

...Thomas Arnason; Heidi L. Sapp; Penelope J. Barnes; Magdalena Drewniak; Mohamed Abdolell; Daniel Rayson Background and Aims: There has been limited study of estrogen and progesterone receptor (ER/PR) expression in gastrointestinal neuroendocrine tumors (GINETs) despite emerging evidence of hormone...