...Rachel Morano; Emily Yates; Rachel Barnes; Eric S. Wohleb; Diego Perez-Tilve Objectives: The control of energy balance relies on the counterbalancing release of neuropeptides encoded by the pro-opiomelanocortin ( Pomc ) and agouti-related protein ( Agrp ) genes, expressed by 2 distinct neuronal...

...). In the present study, we investigated the impact of MT1 receptor deficiency on feeding behavior, locomotor activity and mRNA expression levels encoding for the polypeptide pro-opiomelanocortin (Pomc) and neuropeptide Y (Npy) in the hypothalamic arcuate nucleus (ARC) and the adenohypophysis [pars distalis (PD...

..., the mechanisms underlying its anorexigenic effects remain to be identified. Methods: We first examined the effects of apoA-IV on cellular activities in hypothalamic neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) and in neurons that express pro-opiomelanocortin (POMC). We...

...Dana I. Briggs; Zane B. Andrews Ghrelin plays an important role in energy metabolism by regulating food intake, body weight and glucose homeostasis. In this review, we highlight recent developments describing how ghrelin stimulates neuropeptide Y (NPY) neurons, but not pro-opiomelanocortin neurons...

..., but overall NPY expression was similar in fat and normal animals. Pro-opiomelanocortin (POMC) and leptin receptor (ObRb) expression in the ARC was similar across groups. Orexin (ORX) and melanin-concentrating hormone (MCH) expression was inversely correlated to adiposity, being higher in lean and lower in fat...

... ]. The second subpopulation of neurones expresses the precursor molecule, pro-opiomelanocortin (POMC), from which the melanocortin peptides are derived [ 11 ] (fig. 1 ). Within the ARC, POMC is cleaved to produce the anorexigenic peptides, α-melanocyte-stimulating hormone (α-MSH) and cocaine- and amphetamine...

... and a pro-opiomelanocortin (POMC)-expressing neuron population in its ventrolateral part. Furthermore, both neuropeptide Y Y1 and Y2 receptors (Y1-Rs and Y2-Rs) are expressed in the arcuate nucleus. Here we analyse the co-expression of NPY and POMC/adrenocorticotropic hormone with the Y1-R and Y2-R...

...Bianca B. Ruzicka; Huda Akil Considerable evidence supports the existence of a bidirectional communication between the immune system and the hypothalamo-pituitary-adrenal (HPA) axis. In the present study, we examined the interleukin-1β (IL1β)-mediated regulation of pro-opiomelanocortin (POMC...

..., instructions or products referred to in the content or advertisements. Vasopressin Vasopressin receptors Histamine Stress ACTH β-Endorphin Pro-opiomelanocortin Hypothalamic Adrenal Axis Ncuroendocrinology 1993:58:588-596 Andreas Kjcer Ulrich Knigge Flemming W. Bach Jorgen Warberg Department...

...Andreas Kjær; Ulrich Knigge; Flemming W. Bach; Jørgen Warberg Arginine vasopressin (AVP), corticotropin-releasing hormone (CRH) and catecholamines seem to be involved in the histamine- (HA) and/or stress-induced release of the pro-opiomelanocortin-derived peptides adrenocorticotropic hormone (ACTH...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Histamine Stress ACTH β-Endorphin Pro-opiomelanocortin Vasopressin Vasopressin antagonists Vasopressin receptors...

...Delia M. Vázquez; Huda Akil The dynamics of pro-opiomelanocortin (POMC) biosynthesis in the adult rat are altered by demands imposed on the system, such that acute stress increases in the efficiency of anterior pituitary (AP) posttranslational events, while repeated stress increases...

...Yiai Tong; Georges Pelletier It is well known that the opiate peptides, especially the pro-opiomelanocortin (POMC)-related peptide β-endorphin, stimulate the release of prolactin (PRL) in the rat. In order to evaluate the involvement of PRL on the activity of POMC neurons in the arcuate nucleus, we...

... at the pituitary level, we have studied the localization of pro-opiomelanocortin (POMC) mRNA, and glucocorticoid receptor (GR) mRNA, in human anterior pituitaries, and quantified these messages relative to controls. Pituitaries from 7 suicide victims and 11 cardiac deaths were sectioned into 10-µm slides, stained...

...-Melanocyte-stimulating hormone Melanotrope Pars intermedia Folliculo-stellate cell Neuropeptide Y Pro-opiomelanocortin Xenopus laevis Neiiroendocrinology 1991;54:68-76 © 1991 S. Karger AG. Basel 0028-3835/91/0 5 4 1-0068 S 2.75/0 Indirect Action of Elevated Potassium and Neuropeptide Y on aM SH...

...James H. Meador-Woodruff; Benedetto Pellerito; David Bronstein; Hsia-Lien Lin; Nicholas Ling; Huda Akil The effects of chronic haloperidol treatment on pro-opiomelanocortin (POMC) synthesis, processing, and release in the anterior (AL) and intermediate (IL) lobes of the rat pituitary were studied...

...Sharon L. Wardlaw; Mariann Blum Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we...

... expression in male and female rats. We used in situ hybridization to examine the mRNA levels of hypothalamic peptides which stimulate and inhibit food intake and found selective effects primarily in the arcuate nucleus. Neuropeptide Y (NPY) mRNA was increased and pro-opiomelanocortin (POMC) and galanin (GAL...

...Julie A. Chowen; Jesús Argente; Linda Vician; Donald K. Clifton; Robert A. Steiner We have previously demonstrated that neurons in the rostral arcuate nucleus expressing the messenger RNA (mRNA) for pro-opiomelanocortin (POMC) are responsive to modulation by physiological levels of testosterone...

...Sharon L. Wardlaw Testosterone and estradiol have been shown to affect the hypothalamic content of several pro-opiomelanocortin (POMC)-derived peptides in castrated male and female rats, respectively. It was unclear, however, whether the effects of testosterone on hypothalamic POMC were due...