... and smaller blood pressure elevation of 18 mm Hg at 5 min after injection. To determine whether the hypertensive effects of both RU 24969 and p-chloroamphetamine could mask their effects on renin secretion, rats were pretreated with the α 1 antagonist prazosin. Administration of prazosin (1 mg/kg s.c), which...

...-adrenergic agonist, methoxamine, or the antagonist, prazosin, in rats pre treated with colchicine. Immunohistochemical staining was performed by the peroxidase technique on 40 µm free-floating sections using a polyclonal antibody specific for CRH. In the first experimental model, rats were implanted with icv...

... in the suppression of LH release during acute fasting are examined by injecting the α 2 -antagonist (prazosin), β-antagonists (idazoxan, SKF 86466-A, piperoxan), or β-antagonist (propranolol) into the third ventricle of unfasted and 48 h fasted ovariectomized estradiol-treated rats. Blood samples were collected...

...Maria Gearing; Ei Terasawa It has been postulated that catecholamines are integral to the control of LHRH release. In the present study, the roles of adrenergic and dopaminergic receptors in the control of pulsatile LHRH release are examined. The effects of prazosin (an αi-antagonist), rauwolscine...

...Barbara J. Wilcox; Murray A. Raskind; Grant N. Ko; Denis G. Baskin; Marcella Pascualy; Daniel M. Dorsa Using 3 H-prazosin, we have examined the distribution of α 1 -adrenergic receptors in the supraoptic and paraventricular nuclei of the human hypothalamus. Our studies show that binding sites for 3...

... to α-adrenoceptor antagonists and/or morphine were studied by peripheral administration of prazosin, a selective αi-adrenoceptor antagonist, and yohimbine, a selective α 1 -adrenoceptor antagonist, in conscious, unstressed or ether-stressed rats. The test substances were administered intravenously...

.../kg). Treatment with 0.25 mg/kg virtually eliminated ejaculatory behavior, without altering the number of animals mounting and intromitting. These effects were maintained for at least 4 h after treatment. Prazosin, another antihypertensive (but acting by blockade of α 1 -adrenoceptors), increased...

... administration of prazosin, a selective alphai-adrenergic antagonist, on the secretion of GH, PRL and cortisol was found in any of 7 subjects. Prazosin inhibited blood pressure increase during hypoglycemia and induced slight drowsiness and fatigue in the subjects. It is concluded that in man alpha-adrenergic...