... Pharmacological Studies on the Serotoninergic and Nonserotonin-Mediated Stimulation of Prolactin and Corticosterone Secretion by Fenfluramine Effects of Pretreatment with Fluoxetine, Indalpine, PCPA, and L-Tryptophan Louis D. Van de Kara, Janice H. Urban*. Kathy D. Richardson*. Cynthia L. Betheab *Loyola...

... at 22.00 h, thus amplifying the normally occurring daily fluctuations in hypothalamic 5HT content. To test whether these changes in hypothalamic 5HT are associated with progesterone’s effect on LH surges, p-chlo-rophenylalanine (pCPA) which blocks 5HT synthesis was administered to estrogen-treated as well...

...Richard F. Walker The purpose of this study was to determine if the circadian rhythm in hypothalamic serotonin (5HT) contributes to the facilitatory effect of the amine upon estrogen-induced luteinizing hormone (LH) surges in ovariectomized rats. p-Chlorophenylalanine (pCPA; 250 mg/kg) blocked 5HT...

... before and 15, 30, 60 and 120 min after suckling had resumed. Lactating mothers were treated at various intervals before the experiment with P-chlorophenylalanine (PCPA), an inhibitor of serotonin (5-HT) synthesis; some animals were treated in addition with 5-hydroxytryptophan (5-HTP), a direct precursor...

... by adrenalectomy. Normal and 3-week adrenalectomized (ADX) male rats were either acutely treated 24 h before sacrifice with parachlorophenylalanine methyl ester (PCPA, 250 mg/kg, i.p. injection), or were subjected to lesions of the nuclei centralis superior and raphe dorsalis, chief sites of serotonin(5-HT...