...Xiaolin Chen; Zhuoni Xiao; Qing Liu; Deng Luo; Yuli Cai; Mingxia Fan Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have shown neuroprotective effects in obese mice. However, whether SGLT2i can ameliorate high-fat diet (HFD)-related ovulation disorders remains unknown. The aim...

... the hormonal milieu needed for follicular development and maturation of eggs, but cycles, in and of themselves, do not guarantee ovulation will occur. Here, we review the roles in female reproductive neuroendocrine function of two hypothalamic populations that produce the neuropeptide kisspeptin, demonstrating...

... ]. Neurokinin B Kiss1 Dynorphin Estrous cycle Ovulation © 2015 S. Karger AG, Basel 2015 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic...

... ventricle of 30-day-old female rats advanced the time of vaginal opening (VO) and first ovulation by 4 days, as compared to saline-treated controls. Ova number and ovarian, adrenal and uterine weights at first estrous were similar in all animals regardless of treatment. The NPY-treated precocious animals...

...S. Tiffany Cunningham; Jay S. Rosenblatt; Barry R. Komisaruk Reflexive ovulation in the rat, induced by caesarian section performed on day 22 of pregnancy, was blocked by prior bilateral transection of the pelvic and/ or hypogastric nerves, which convey afferent activity from the reproductive tract...

... hormone (LH) and occurrence of ovulation. The effect of acute administration into anaesthetised rats of selective D 1 and D 2 dopamine agonists and antagonists injected into the ZI on plasma luteinizing hormone (LH) and on the occurrence of ovulation has now been investigated. It was found that bilateral...

... carrier, the resulting carrier E 2 complex (CE), upon a single intravenous administration to cycling female rats, caused a dose-dependent inhibition of ovulation which lasted 3 times longer than with uncoupled E 2 . The dose of CE that delayed ovulation for 4 days was one twentieth the amount of E 2...

...Laura L. Murphy; Lee Tyrey The predominant psychoactive constituent of marijuana, Δ 9 -tetrahydrocannabinol (THC), blocks the preovulatory luteinizing hormone (LH) surge and ovulation in rats treated with THC (10 mg/kg body weight) during the early afternoon of proestrus. When THC-blocked...

...Katalin Köves; Judith Molnár Various supra- and retrochiasmatic cuts injuring different parts of the septo-preoptico-infundibular GnRH pathway were made in adult female rats, and their effects on ovulation, median eminence (ME) GnRH content and on plasma LH and FSH levels were studied. Extended...

... levels, E evoked a significant 2-fold rise in plasma LH levels. Quite unexpectedly, however, infusion of E (18.5 µg) over a 30-min period during the critical period failed to either reverse the pentobarbital-blockade of ovulation or stimulate LH release. Prior suppression of E levels selectively with LY...

...Richard Sheaves; Robert Laynes; Pamela MacKinnon Groups of 4-day cyclic rats were injected (i.p.) with LY 134046 (50 mg/kg), a central inhibitor of phenylethanolamine N-methyltransferase, or saline at 09.00, 13.00 and 19.00 h on the day of proestrus. The incidence of ovulation was examined...

...Fiona J. MacKenzie; A. Jaqueline Hunter; Clyde Daly; Catherine A. Wilson 2 µg dopamine (DA) were injected into particular hypothalamic sites containing dopaminergic nerve terminals, on the morning of pro-oestrus in cyclic rats, in which ovulation was blocked by administration of 35 mg/kg pento...

...Richard J. Krieg, Jr.; John.R. Cassidy Previous experiments showed that haloperidol (Haldol) blocked LH release and ovulation when injected on the day of proestrus in the female rat. The present studies were designed to investigate the mechanism of Haldol blockade and the possibility...

... in persistent-estrous rats were elevated, progesterone levels remained low. These findings appear to show that the estrous cycles in LL rats are composed of circaquadridian secretion rhythms, longer than 96 h, of gonadotropins and sex steroids so that the estrous cycles are lengthened and the ovulation...

...Richard J. Krieg, Jr.; James H. Johnson The capacity of haloperidol (Haldol) to block luteinizing hormone (LH) release and ovulation was investigated with particular reference to its effectiveness during the ‘critical period’ on the afternoon of proestrus in normal, cycling female rats. Haldol...

... by stimulation of the mPOA. Lesions in the LHA or PMA also prevented the blockade of ovulation and discharge of LH on the day of proestrus induced by electrochemical stimulation of the anterior cingulate area. Besides, electrolytic lesions of the ascending noradrenergic pathways at the level of the dorsal...

... in neonates results in a delay of vaginal opening (VO) and the absence of ovulation at the time of VO. However, some rats were observed to ovulate after VO if they were subjected to sequential laparotomies. MSG-treated rats also fail to exhibit compensatory ovarian hypertrophy. Ovariectomized MSG-treated rats...

...Alberto J. Carrillo Bilateral electrochemical stimulation (ECS) of the ventral hippocampus (VHPC) or dorsal hippocampus (DHPC) under acute conditions at 10.00, 12.00 or 13.00 h on proestrus did not interfere with ovulation. When the same ECS of the VHPC was repeated at 12.00 h of proestrus followed...

... the preovulatory discharge of LH and ovulation. Blockade of ovulation also occurred when the stimulus was applied in the lateral or medial parts of the superficial layers. On the other hand, stimulation in the dorsal part blocked the preovulatory surge of LH and ovulation in only 50% of the cases. Stimulation...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hypothalamic deafferentation Newborn female rats Ovulation Estrous cycle Neuroendocrinology 28: 145-150 (1979) Spontaneous Ovulation in Rats after Interruption...