... of endogenous sex hormones on the analgesic modulation of tramadol in lean and high-fat diet-induced obese Wistar rats. Methods: The whole study was carried out on 48 adult Wistar rats (24 male: 12 obese and 12 lean and 24 female: 12 obese and 12 lean). Each male and female rat group was further subdivided...

...Carla Elena Mezo-González; Juan Antonio García Santillán; Luis Antonio Reyes-Castro; Mathilde Gourdel; Mikaël Croyal; Francisco Bolaños-Jiménez Introduction: Obesity is associated with impaired learning, but the mechanisms underlying this cognitive dysfunction are poorly understood. Moreover...

...Qiwen Wu; Jingmei Chen; Tingyu Hua; Jinyan Cai Understanding the complex action mechanism of appetite regulation peptides can significantly impact therapeutic options in the treatment of obesity and other metabolic diseases. Hypothalamic alpha-melanocyte-stimulating hormone (α-MSH...

... Introduction: The aim of the study is to investigate whether acute or chronic central administration of the hypothalamic neuropeptide 26RFa may ameliorate the glycemic control of obese/diabetic mice. Methods: Mice were treated for 4 months with a high-fat (HF) diet and received a single i.c.v. injection...

...Yasmine V. Doust; Nicole Sumargo; Jenna M. Ziebell; Dino Premilovac Increased intake of highly processed, energy-dense foods combined with a sedentary lifestyle are helping fuel the current overweight and obesity crisis, which is more prevalent in women than in men. Although peripheral organs...

...Ahmet Yardimci; Nazife Ulker; Ozgur Bulmus; Elif Sahin; Ahmet Alver; Ibrahim Halil Gungor; Gaffari Turk; Gokhan Artas; Nalan Kaya Tektemur; Mete Ozcan; Haluk Kelestimur; Sinan Canpolat Introduction: Obesity is known to cause sexual dysfunction including erectile dysfunction and poor semen quality...

...Ana Paula Santos; Carlos Ferreira Couto; Sofia Silva Pereira; Mariana Pereira Monteiro COVID-19 is an intriguing infectious condition with multisystemic manifestations and variable outcomes that are influenced by the concomitant presence of non-communicable diseases, such as obesity, diabetes...

... and obesity that can affect hormone production will affect neuroendocrine control of maternal neurogenesis. However, there is a lack of information about the regulation of maternal neurogenesis by placental hormones, which are key components of the reproductive hormonal profile during pregnancy. There is also...

...Yuki Narimatsu; Eiko Iwakoshi-Ukena; Keisuke Fukumura; Kenshiro Shikano; Megumi Furumitsu; Masahiro Morishita; George E. Bentley; Lance J. Kriegsfeld; Kazuyoshi Ukena Introduction: The mechanisms underlying obesity are not fully understood, necessitating the creation of novel animal models...

.... Methods: We used fluorescence-activated cell sorting followed by quantitative polymerase chain reaction and fluorescent in situ hybridization to measure Pomc and Agrp gene co-expression in POMC or AGRP neurons in response to (1) acute or chronic calorie restriction, or (2) obesity due to loss of leptin...

... and progression of overweight and obesity, leading to several chronic diseases, such as diabetes, and mental health disorders. The interplay of biological and psychometric correlates of stress, anthropometric, immunological, and metabolic parameters and psychosocial factors such as gender roles, however, remains...

.... UGN is the endogenous ligand of Gucy2c and decreases body weight in diet-induced obese (DIO) mice via the activation of the thermogenic program in brown adipose tissue. Therefore, we wanted to evaluate whether oral linaclotide could also improve DIO mice metabolic phenotype. In this study, we have...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Enteric nervous system Diabetes Obesity The enteric nervous system (ENS), referred to as the “second brain...

...Jian Qiu; Martha A. Bosch; Chungang Zhang; Oline K. Rønnekleiv; Martin J. Kelly When it comes to obesity, men exhibit a higher incidence of metabolic syndrome than women in early adult life, but this sex advantage wanes in postmenopausal women. A key diagnostic of the metabolic syndrome is insulin...

...Eglantine Balland; Weiyi Chen; Tony Tiganis; Michael A. Cowley Background: Obesity is associated with reduced physiological responses to leptin and insulin, leading to the concept of obesity-associated hormonal resistance. Objectives: Here, we demonstrate that contrary to expectations, leptin...

... autopsy cases (17 males, 8 females; 8 lean, 9 overweight, 8 obese) were examined using immunohistochemistry and double immunofluorescence labeling. Results: Prominent NUCB2/nesfatin-1 immunoexpression was detected in supraoptic, paraventricular, and infundibular nuclei, lateral hypothalamic area (LHA...

...Clara Roujeau; Ralf Jockers; Julie Dam Endospanin 1 (Endo1), a protein encoded in humans by the same gene than the leptin receptor (ObR), and increased by diet-induced obesity, is an important regulator of ObR trafficking and cell surface exposure, determining leptin signaling strength. Defective...

... regulation and the anorexigenic neural pathway of oxytocin neurons, as well as the advantage of oxytocin usage for anti-obesity treatment. maejimay@fmu.ac.jp 13 11 2017 15 04 2018 16 4 2018 © 2018 S. Karger AG, Basel 2018 Copyright / Drug Dosage / Disclaimer Copyright: All...

...Gilles Mithieux A large number of genomic studies have reported associations between the gut microbiota composition and metabolic diseases such as obesity or type 2 diabetes. This led to the widespread idea that a causal relationship could exist between intestinal microbiota and metabolic diseases...

...Belinda A. Henry The incidence of obesity is rapidly escalating and has reached epidemic proportions. In all species, including rodents, humans, and sheep, there is large variation in the degree of weight gain across individuals in response to an obesogenic environment. This individual variation...