... cyclicity. Individually, kisspeptin and nitric oxide (NO) influence GnRH secretion. However, it is possible these 2 neuronal intermediates interact with one another to affect reproductive cyclicity. Methods: We investigated the neuroanatomical relationship of one isoform of the enzyme that synthesizes...

... were measured in the LA. Results: LA-LTP induced by stimulation of the external capsule was nitric oxide (NO)-dependent because the NO synthase (NOS) inhibitor L -NAME reduced LA-LTP. The LA-LTP was also reduced in both male and female nNOS and eNOS knockout mice. In male eNOS –/– mice, Ang-(1–7...

... prostaglandin E 2 (PGE 2 ) production linked to an increase in constitutive cyclooxygenase (COX) expression. The nitric oxide (NO) synthase inhibitor L -NAME (70 mg/kg, s.c.), the nonselective COX inhibitor indomethacin (10 mg/kg, orally) and capsaicin denervation removed TLQP-21 gastroprotection. Conclusions...

...), a nitric oxide synthase (NOS) inhibitor, the magnitude of the increase in [Ca 2+ ] i evoked by 1 µ M leptin was not significantly changed. However, in the presence of L -NAME only 24% of the somatotropes responded to leptin, while in parallel control cultures 70% of the somatotropes responded to leptin...

... showed that nitric oxide (NO) mediates the inhibitory effect of TNF-α on prolactin release. Here, we studied the effect of TNF-α on nitric oxide synthase (NOS) activity and expression in anterior pituitary cells from cycling and ovariectomized (OVX) rats, and the role of NO in TNF-α induced apoptosis...

...Manuel Tena-Sempere; Leonor Pinilla; Dolores González; Enrique Aguilar Recently, nitric oxide (NO) has emerged as an important modulator of several neuroendocrine events. Present studies were designed in order to evaluate the involvement of endogenous NO in the control of GH secretion. In a first...

...Ganapathy Bhat; Virendra B. Mahesh; Kripamoy Aguan; Darrell W. Brann Recent studies suggest that nitric oxide (NO) may function as a neurotransmitter in the hypothalamus. In order to provide further evidence supporting this contention, we examined: (1) whether the hypothalamus displays significant...

... nitric oxide (NO) synthase (NOS), and that NOS expression is increased by gonadectomy. Using the indirect immunofluorescence technique in conjunction with antibodies raised to conjugated cGMP, we have attempted to establish the target cells for NO in the anterior pituitary and to define the mediator...

...Kripamoy Aguan; Virendra B. Mahesh; Lin Ping; Ganapathy Bhat; Darrell W. Brann Antisense oligonucleotides of brain-nitric oxide synthase (b-NOS) and endothelial-NOS (e-NOS) were used in steroid-primed ovariectomized rats to examine the physiological role of nitric oxide in the regulation of the LH...

...Kazumasa Uemura; Tatsuo Tamagawa; Yi Chen; Noriki Maeda; Shuko Yoshioka; Ken-ichi Itoh; Hisayuki Miura; Akihisa Iguchi; Nigishi Hotta To determine whether the nitric oxide (NO) system in the central nervous system (CNS) is involved in the peripheral metabolism of carbohydrate we injected N G...

...Darrell W. Brann; Ganapathy K. Bhat; Charisee A. Lamar; Virendra B. Mahesh Recent work has demonstrated that the brain has the capacity to synthesize impressive amounts of the gases nitric oxide (NO) and carbon monoxide (CO). There is growing evidence that these gaseous molecules function as novel...

...Carla Micaela Cuttica; Massimo Giusti; Liliana Bocca; Paola Sessarego; Daniele De Martini; Sandra Valenti; Renato Spaziante; Giulio Giordano Nitric oxide (NO) has recently been shown to modulate pituitary secretion both in vivo and in vitro. The aim of this study was to investigate the effects...

...Ganapathy K. Bhat; Virendra B. Mahesh; Charisee A. Lamar; Ling Ping; Kripamoy Aguan; Darrell W. Brann The neurotransmitter glutamate plays an important role in the control of gonadotropin releasing hormone (GnRH) secretion. Recent evidence suggests that the novel transmitter nitric oxide may also...

...Sandra Ceccatelli; Lindsey Grandison; Roderick E.M. Scott; Donald W. Pfaff; Lee-Ming Kow Expression and estrogen regulation of the genes for nitric-oxide (NO)-synthesizing enzymes (NO synthase, NOS) were investigated by in situ hybridization. This study focused on regions of the hypothalamus...

... to study whether the gas molecule nitric oxide might be included among the effector systems involved in such rapid corticosterone effect. The administration of nitric oxide synthase inhibitors, given either sys-temically [N G -nitro-L-arginine methyl ester (L-NAME), 30 mg/kg body weight, i.p.] or centrally...

...Manuel O. López-Figueroa; Jean P. Ravault; Bruno Cozzi; Morten Møller By use of immunohistochemistry, a dense network of nerve fibres immunoreactive to the neuronal form of nitric oxide synthase (NOS, subtype I) was demonstrated in the pineal gland of sheep. The NOS-immunoreactive fibres were...

...Masahiro Ota; Joan T. Crofton; Gregory T. Festavan; Leonard Share Nitric oxide (NO) is the endothelium-derived relaxing factor, which causes relaxation of vascular smooth muscle. NO synthetase, the enzyme for the synthesis of NO from its precursor L-arginine, is also widely distributed in neurons...

...Rainer Spessert; Elisabeth Layes; Gabriele Hill; Lutz Vollrath In the rat pineal, formation of the second messenger cyclic GMP (cGMP) is under adrenergic control. Two important sequential steps mediate adrenergic signal transduction by cGMP, receptor-stimulated nitric oxide (NO) formation...

... to analyze the effects of neonatal handling on noradrenaline (NA) and nitric oxide (NO) levels in the MPOA on the afternoon of proestrus. Neonatal handling reduced MHPG (NA metabolite) levels and MHPG/NA ratio in the MPOA, indicating decreased NAergic activity. Additionally, neonatal handling decreased...

... therapeutics. Gonadal steroids Gonadal steroid receptors Transcription factors Nitric oxide Gonadotropins Gonadotropin-releasing hormone Every field of biological research seems to have a development similar to that of European architecture: from classical simplicity to the floridity of high...