...Noah C. Helderman; Manon Suerink; Gül Kilinç; José G. van den Berg; Maartje Nielsen; Margot E.T. Tesselaar Practice of neuroendocrine neoplasms (NENs) of the digestive tract, which comprise of a highly diverse group of tumors with a rising incidence, faces multiple biological, diagnostic...

...Beth Russell; Benjamin E White; Brian Rous; Kwok Wong; Catherine Bouvier Ellis; Rajaventhan Srirajaskanthan; Mieke Van Hemelrijck; John K Ramage Introduction: Patients with neuroendocrine neoplasms (NENs) may often develop other malignancies. This study aimed to identify the frequency at which...

... as a prognostic factor is also shared with mixed GEP-NECs (mixed neuroendocrine neoplasms) neoplasms [ 19 ] and pure and combined LCNECs [ 21 ]. Similar to GEP-NEC, and especially in the colon-rectum, Ki-67 ≥55% in the neuroendocrine component is associated with the worst prognosis and shares morphological...

...Qing Xie; Ming Lu; Shizhen Zhai; Rui Guo; Changzhi Du; Hua Zhu; Nan Li; Jiangyuan Yu; Zhi Yang Purpose: This study aimed to analyze neuroendocrine neoplasm (NEN) bone metastasis (BM) and gallium-68 ( 68 Ga)-DOTA-TATE performance and to explore their correlation with the immunohistochemical...

...David L. Chan; Elizabeth J. Bernard; Geoffrey Schembri; Paul J. Roach; Meaghan Johnson; Nick Pavlakis; Stephen Clarke; Dale L. Bailey Introduction: 18-Fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) avidity in neuroendocrine neoplasms (NENs) has been associated with higher-grade...

...Alison May Berner; Christodoulos Pipinikas; Anna Ryan; Harpreet Dibra; Ismail Moghul; Amy Webster; Tu Vinh Luong; Christina Thirlwell Neuroendocrine neoplasms (NENs) arise from cells of neuronal and endocrine differentiation. While they are a rare entity, an increasing proportion of patients...

...Ashley Kieran Clift; Mark Kidd; Lisa Bodei; Christos Toumpanakis; Richard P. Baum; Kjell Oberg; Irvin M. Modlin; Andrea Frilling The traditionally promulgated perspectives of neuroendocrine neoplasms (NEN) as rare, indolent tumours are blunt and have been outdated for the last 2 decades. Clear...

... neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accuracy and prognostic impact. Two BP-NEN cohorts from Japan and Germany, 393 tumors (88% surgically resected...

...Taymeyah Al-Toubah; Michael J. Schell; Mauro Cives; Jun-Min Zhou; Heloisa P. Soares; Jonathan R. Strosberg Background: Ibrutinib is an orally administered inhibitor of Bruton’s tyrosine kinase (Btk). Preclinical data suggest that mast cells are recruited within neuroendocrine neoplasms (NENs) where...

... the grading of pancreatic neuroendocrine neoplasms from a three-tier (WHO-AJCC 2010) to a four-tier system by introducing the novel category of NET G3 (WHO-AJCC 2017). Objectives: This study aims at validating the WHO-AJCC 2017 and identifying the most effective grading system. Method: A total of 2,102...

...Halfdan Sorbye; Eric Baudin; Ivan Borbath; Martyn Caplin; Jie Chen; Jaroslaw B. Cwikla; Andrea Frilling; Ashley Grossman; Gregory Kaltsas; Aldo Scarpa; Staffan Welin; Rocio Garcia-Carbonero; ENETS 2016 Munich Advisory Board Participants Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN...

... with neuroendocrine neoplasms (NENs). Several conditions and comorbidities may be associated with falsely elevated CgA, often leading to extensive diagnostic evaluation, which may be costly and harmful. The aim of this study was to analyze the effectiveness of the acute octreotide suppression test (AOST...

... in neuroendocrine neoplasms (NEN) concerning follow-up and documentation are considered in this review. The documentation of patients with NEN should include the most relevant data characterizing an individual patient from the first contact with his/her physician/hospital until his/her last presentation during...

..., instructions or products referred to in the content or advertisements. 2014 Neuroendocrine neoplasm Pancreatic neuroendocrine tumor Positron emission tomography ⁶⁸Gallium ¹⁸FDG Pancreatic neuroendocrine tumors (PNETs) comprise a wide...

.... Merkel cell carcinoma Neuroendocrine neoplasm Merkel cell polyomavirus Massively parallel sequencing National Institutes of Health (NIH) 10.13039/100000002 Merkel cell carcinoma (MCC) is a relatively rare neuroendocrine cancer with poor prognosis that is seen with increasing...