...Omar Abdel-Rahman; Sheryl L. Koski Objective: This study aimed to assess the survival differences between cisplatin/etoposide versus carboplatin/etoposide chemotherapy regimens in the management of patients with extrapulmonary neuroendocrine carcinomas (NECs). Methods: Administrative cancer care...

... and 83.7% TEM) with a median age of 59 years (range 26–85) years. ECOG performance status was 0–2. Carcinoid syndrome was reported in 12 (12.6%) patients. Twenty (21.1%) patients with grade (G) 3 neuroendocrine carcinoma (NEC) and 9 (9.4%) with G3 neuroendocrine tumors (NETs) were included in the analysis...

...Laura Gerard; Jessica Garcia; Arnaud Gauthier; Jonathan Lopez; Alice Durand; Valérie Hervieu; Annie Lemelin; Laurence Chardon; Verena Landel; Benjamin Gibert; Catherine Lombard-Bohas; Lea Payen; Thomas Walter Introduction: Gastroenteropancreatic neuroendocrine carcinomas (GEPNEC) are characterized...

... tract and pancreas. GEP-NENs are subdivided according to their differentiation into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Since GEP-NENs represent rare diseases, only limited data from large prospective, randomized clinical trials...

... type), paraganglioma, non-small/large cell neuroendocrine carcinoma (NEC), mixed NEC, or undifferentiated carcinomas at 20 institutions in Japan were included in this retrospective cross-sectional study. We identified O-NENs through central pathological review using a common slide set, followed...

...Wouter T. Zandee; Jan Maarten van der Zwan; Wouter W. de Herder; Marie-Louise F. van Velthuysen Background: Neuroendocrine carcinomas (NECs) are diagnosed through a combination of immunohistochemistry (IHC) and morphology according to WHO guidelines. The presence of these crucial components...

... as first-line chemotherapy for unresectable pancreatic neuroendocrine carcinoma (NEC), but second-line chemotherapies have yet to be established. Objectives: We evaluated the safety and efficacy of everolimus in patients with pancreatic NEC refractory or intolerant to platinum-containing chemotherapy...

... of developing a malignancy compared with the general population. Second radiation-induced malignancies with different histologies have been described in different organs. Based on individual observations, we hypothesized that neuroendocrine carcinoma (NEC) could arise in irradiated organs. Methods...

...) are classified based on morphology and graded based on their proliferation rate as either well-differentiated low-grade (G1 to G2) neuroendocrine tumors (NET) or poorly differentiated high-grade (G3) neuroendocrine carcinomas (NEC). Recently, a new subgroup of well-differentiated high-grade pancreatic tumors...

... the dedifferentiation of the tumor into a neuroendocrine carcinoma G3 (Ki-67 of 80%) including a nonfunctional stage. Bertram.Wiedenmann@charite.de 11 08 2017 7 12 2017 20 12 2017 © 2017 S. Karger AG, Basel 2017 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Neuroendocrine neoplasm Neuroendocrine tumor Neuroendocrine carcinoma Follow-up TNM staging Chromogranin A Neuron-specific enolase 5-Hydroxyindoleacetic acid NT-pro-brain...

...: Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are defined as neuroendocrine neoplasms (NENs) with a Ki-67 index >20% according to the 2010 WHO classification. Some reports suggest that this category is heterogeneous. We retrospectively studied a series of 136 patients affected by grade 3 GEP-NECs...

... Incidence Neuroendocrine carcinoma Carcinoid Neuroendocrine tumours (NETs) comprise a heterogeneous group of neoplasias originating in a broad diversity of tissues and showing a broad and only partially understood spectrum of clinical behaviour. The term Karzinoid was first used in 1907...

..., instructions or products referred to in the content or advertisements. Mixed carcinoma Neuroendocrine carcinoma Gene expression Thymidylate synthase Prognosis The concept of human cancers displaying a combination of neuroendocrine and nonneuroendocrine (glandular, squamous or urothelial...