... that exposure to EMF may represent a mild stressor and contribute to disturbances of the hypothalamic-pituitary-adrenal (HPA) axis. The important regulatory pathways controlling HPA axis activity include two types of corticosteroid receptors: mineralocorticoid receptors (MRs) and glucocorticoid receptors...

.... The temporal role for cortisol signalling in the stress-related hyperactivity was tested using the glucocorticoid receptor knockout (GRKO) and mineralocorticoid receptor knockout (MRKO) zebrafish mutants. Results: CRHR1-KO larvae did not increase cortisol, the principal GC in teleosts, post-stress, confirming...

... the glucocorticoid receptor, as well as the mineralocorticoid receptor, the cortisol-releasing hormone receptor-1, and the glucocorticoid receptor co-chaperone FKBP5. Data clearly indicate genetic changes, along with epigenetic changes which influence the set-point and regulation of the HPA axis. Early trauma...

...Elise P. Gomez Sanchez The mineralocorticoid receptor (MR) is expressed in many cell types throughout the body, including specific neurons, and mediates diverse functions, many of which are just now being appreciated. MR that pertain to the central modulation of cardiovascular function and health...

...Christoph Dodt; Werner Kern; Lorenz Fehm; Jan Born In rats, both hippocampal glucocorticoid and mineralocorticoid receptors (MR) have been shown to participate in the regulation of basal hypothalamus-pituitary-adrenocortical (HPA) secretory activity. Inhibition of hippocampal MRs enhanced...

...Mike Clark; Mark A. Smith; Susan R.B. Weiss; Robert M. Post In situ hybridization was used to examine the effects of amygdala kindling on the expression of mRNAs for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the rat hippocampus. Kindling increased MR mRNA levels...

.... Footshocks Stress Hippocampus Mineralocorticoid receptor Glucocorticoid receptor Vasopressin CRF ACTH Corticosterone Behaviour Rat 19 10 1992 19 03 1993 8 4 2008 © 1993 S. Karger AG, Basel 1993 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... Mineralocorticoid receptor Original Paper Neuroendocrinology 1993 ;57:96-105 Seung P. Kwak Maria I. Morano Elizabeth A. Young Stanley J. Watson Huda Akil The Mental Health Research Institute, University of Michigan, Ann Arbor, Mich., USA Diurnal CRH m RNA Rhythm in the Hypothalamus: Decreased Expression...

...Jonathan R. Seckl; George Fink Adrenal corticosteroids bind to hippocampal glucocorticoid (GR) and mineralocorticoid receptors (MR), thereby affecting neurochemical transmission leading to altered mood, behaviour and neuroendocrine control. Serotoninergic (5-HT) and noradrenergic projections...

...Marian Joëls; E. Ronald De Kloet In a previous study we showed that selective occupation of the mineralocorticoid receptor (MR) in hippocampal slices from adrenalectomized (ADX) rats attenuates the membrane hyperpolarization and resistance decrease induced in CAl pyramidal neurons by serotonin (5HT...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Corticotropin-releasing factor Corticosterone Circadian rhythm mRNA regulation Mineralocorticoid receptor Glucocorticoid receptor Original...

...Mayumi Nishi; Mitsuhiro Kawata Adrenal corticosteroids (cortisol in humans/corticosterone in rodents) readily enter the brain and exert markedly diverse effects, such as the stress response of target neural cells. These effects are regulated via two receptor systems, the mineralocorticoid receptor...