... postnatal days (PNDs) 2–6. In in vitro studies, mHypoA-POMC/GFP cells were treated with ethanol (50 m<sc>M</sc>) for a 24-h period. Hypothalamic tissues or cell extracts were used for measurement of miRNAs and POMC mRNA. Results: Determination of genome-wide microRNA expression profile...

...; in this work, we integrated mRNA- and microRNA (miRNA)-level transcriptome data that exploit disease-specific signatures in addition to biological and pharmacological data to elucidate a rational prioritization of pathways and drugs in prolactinoma. Results: We identified 8 drug candidates through drug...

... is known about their microRNA (miRNA) expression. The purpose of this study was to characterize the expression of miRNAs in SI-NEN and to determine the potential of miRNAs as noninvasive blood-based biomarkers. Methods: miRNA was purified from 15 tumor and 7 control tissue samples, converted to cDNA...

... neuroendocrine tumors (GI-NETs) have a common origin. MicroRNA (miRNA) expression may clarify their genetic relationships and origin. Methods: First, we compared the miRNA expression signature of formalin-fixed paraffin-embedded (FFPE) samples with frozen samples to verify the applicability of microarray...

... hippocampi were micro-dissected (for mRNA, microRNA, and DNA methylation analysis) or frozen whole (for chromatin immunoprecipitation). In an additional experiment, rats were pre-treated with RU486 (a GR antagonist) or vehicle. Results: FSS evoked a dentate gyrus-specific reduction in GR mRNA levels...

...Ida Rapa; Arianna Votta; Barbara Felice; Luisella Righi; Jessica Giorcelli; Aldo Scarpa; Ernst-Jan M. Speel; Giorgio V. Scagliotti; Mauro Papotti; Marco Volante Aim: To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features...

..., instructions or products referred to in the content or advertisements. Fiber Hexon Neuroendocrine tumors Oncolytic virus Adenovirus Promoter MicroRNA The use of oncolytic viruses that preferentially infect, replicate in and destroy tumor cells is an emerging therapeutic approach for cancer...