... is orexigenic and decreases energy expenditure whereas α-MSH reduces food consumption and stimulates catabolism. α-MSH is an endogenous ligand for the central melanocortin receptors, MC3-R and MC4-R. In order to determine whether α-MSH may act directly on NPY neurons in the arcuate nucleus, we have investigated...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Melanocyte-stimulating hormone Melanocortin receptors Prolactin Lactotropes Gonadal steroids Mice Growth hormone...

... in cultured macrophages and NO production in liver and microglia [ 4, 17, 19 ]. Also, α-MSH was found to inhibit PGE 2 production in brain tissue [ 20, 21 ]. Melanocortins mediate their effects through G protein-coupled receptors by stimulating adenylate cyclase. To date, five melanocortin receptor...

.... Melanocortins Melanocortin receptors Leptin Growth hormone Pulsatile secretion Leptin is an adipocyte-derived hormone, and serves an important role in body weight homeostasis through reducing food intake and increasing thermogenesis [ 1 ]. In addition to exerting these significant influences...

... is possibly mediated by melanocortin 3-receptors in the mouse anterior pituitary cells. Zool Sci 1998;15:567–572. 8. Cone RD, Lu D, Koppula S, Vage DI, Klungland H, Boston B, Chen W, Orth DN, Pouton C, Kesterson RA: The melanocortin receptors: Agonists, antagonists, and the hormonal control...

... be another receptor independent of the known melanocortin receptors at which Agrp is acting. 17 4 2002 © 2002 S. Karger AG, Basel 2002 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...