... as gastroenteropancreatic neuroendocrine tumors, originate from neuroendocrine cells throughout the pancreas and gastrointestinal tract and are a genomically and clinically heterogeneous group of rare tumors often diagnosed with distant metastases [1]. In fact, neuroendocrine liver metastases (NELMs) are diagnosed in up...

...John Monte Hudson; Hans Tse-Kan Chung; William Chu; Amandeep Taggar; Laura Ellen Davis; Julie Hallet; Calvin How Lim Law; Simron Singh; Sten Myrehaug Introduction: Liver metastases are common in patients with neuroendocrine neoplasms. The role of stereotactic ablative radiotherapy (SABR...

... assessed. Survival analysis was conducted using the Kaplan-Meier and conditional survival (CS) methods. Results: The cohort consisted of 487 patients with a median follow-up of 71 months. Recurrence developed in 12.3%: 54 (11.1%) liver metastases, 11 (2.3%) local recurrence, 10 (2.1%) nodal recurrence...

... for treatment of liver metastases from neuroendocrine tumor (NET). AdVince includes the gene promoter from human chromogranin A for selective replication in neuroendocrine cells, miR122 target sequences for reduced liver toxicity, and a cell-penetrating peptide in the capsid for increased infectivity of tumor...

... neuroendocrine tumors (PNET) with liver metastases (LM) is still debated. The aim of this study was to evaluate the outcomes of surgery of PNET with LM. Methods: Patients with PNET with synchronous LM between 2000 and 2011 from 4 high-volume institutions were included. The patients were divided into 3 groups...

...Frédérique Maire; Catherine Lombard-Bohas; Dermot O’Toole; Marie-Pierre Vullierme; Vinciane Rebours; Anne Couvelard; Anne Laure Pelletier; Magaly Zappa; Frank Pilleul; Olivia Hentic; Pascal Hammel; Philippe Ruszniewski Background: Liver surgery is the best treatment for endocrine liver metastases...

...) and flushing alone (p = 0.028) and associated with diarrhea at diagnosis (p = 0.015), weight loss at diagnosis (p = 0.038), Ki-67 level (p = 0.025), stage of disease at diagnosis (p = 0.012), presence of liver metastases at follow-up (p = 0.005), presence of diffuse metastases at diagnosis (p = 0.005...

... analogues. Other therapeutic options in the treatment of highly vascular liver metastases from GEP tumors are locoregional strategies by inducing vascular occlusion resulting in ischemia and necrosis of tumoral tissue. Surgical ligation of the hepatic artery or transient hepatic ischemia has been replaced...