...Sharon S. Vaala; K.M. Knigge In vitro , median eminence was found to take up 3 H-LRF rapidly, reach equilibrium in approximately 30 min, and achieve an uptake (30 pg LRF/mg) twice that accumulated by anterior pituitary. Conditions which challenged cellular integrity (boiling, treatment...

...F.W. Turek; J.D. Alvis; M. Menaker The effect of various doses of LRF on pituitary LH and FSH release was examined in castrated adult male hamsters with different photoperiodic histories. Gonadotropin (Gn) release in response to LRF was independent of whether the animals had been exposed...

... and FSH levels and a complete block of spontaneous ovulation. Haloperidol significantly reduced hypothalamic PIF and LRF activities. The anti-ovulatory effect of haloperidol was overcome by the administration of exogenous LH. Haloperidol directly inhibited prolactin and LH release by the pituitary...

...- LRF ently suppress LH-controlling mechanisms in the brain, and the negative feedback effects of these intracerebral implants do not result from diffusion to the pituitary gland. The site at which gonadal steroids exert their inhibitory action on gonadotropin secretion by the pituitary has been...