...Hui-Yan Zhang; Guo Shen; Chen Yang; Jian Tan; Jian-Cang Cao; Jing Tian; Zhou-Le Li; Gang Huang; Lian-Ping Zhao Introduction: Insulin resistance is widely thought to be a critical feature in type 2 diabetes mellitus (T2DM), and there is significant evidence indicating a higher abundance of insulin...

...Ye Zhu; Jun Tian; Xiali Wei; Shaohui Jia; Qing Shu Introduction: We investigated the effects of electroacupuncture (EA) on improving obesity and insulin resistance (IR) in high-fat diet-induced (HFDI) obese rats by modulating the nucleus tractus solitarius (NTS) glucagon-like peptide-1 (GLP-1...

.... 2023 Traumatic brain injury Glucagon-like peptide 1 Hyperglycemia Insulin resistance Mortality Cerebrospinal fluid To assess the independent association of risk factors with mortality, a multivariate binary logistic regression model was developed to estimate odds ratios and 95...

... such as adipose tissue contribute to the physiological development of obesity, emerging work aims to understand the role of the central nervous system to whole-body energy homeostasis and development of weight gain and obesity. The present review discusses the impact of insulin, insulin resistance, free fatty...

... genes Adrenal insufficiency Insulin resistance In humans, the endogenous circadian clock regulates a great number of daily physiological and behavioral processes [1, 2]. The master clock, residing in the suprachiasmatic nuclei (SCN) of the hypothalamus, receives information from exogenous...

...Clarissa Menezes Maya-Monteiro; Felipe Corrêa-da-Silva; Susanna S. Hofmann; Matthijs K.C. Hesselink; Susanne E. la Fleur; Chun-Xia Yi Background: In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism, inflammation, and insulin resistance. Little is known about the brain LDs...

...-derived neurotrophic factor (BDNF) levels showed the same tendency; in fact, BDNF significantly decreased only in those patients with worse eating control. Conclusions: Problematic eating behaviors may predict a better response of insulin resistance and a specific reduction of serum BDNF in morbidly obese...

... indicate that insulin action in the brain may affect pancreatic insulin secretion. An important brain region for this process is the hypothalamus, an area that can develop insulin resistance. Methods: Fifteen young, healthy men (27 ± 3 years) with a wide BMI spectrum (20–30 kg/m 2 ) underwent 2...

... protect against insulin resistance in NPY/AgRP neurons with diet-induced obesity (DIO). Therefore, we did whole-cell recordings and single cell quantitative polymerase chain reaction in arcuate NPY GFP neurons from both female and male mice to test the efficacy of insulin with DIO. The resting membrane...

..., hyperinsulinemia and type 2 diabetes. Besides leptin actions in the ARH, insulin also activates the phospho-inositol-3-kinase/Akt signaling cascade through central insulin receptor (InsR) to maintain normal glucose homeostasis [ 18 ]. Insulin resistance in the brain occurs in obesity and may be involved in type 2...

...Weiyi Chen; Eglantine Balland; Michael A. Cowley The central link between obesity and type 2 diabetes is the development of insulin resistance. To date, it is still not clear whether hyperinsulinemia causes insulin resistance, which underlies the pathogenesis of obesity-associated type 2 diabetes...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Polycystic ovary syndrome Obesity Hyperandrogenism Insulin resistance Cardiometabolic risks Other neuroendocrine abnormalities observed in PCOS, including elevation...

... to obesity per se or to the metabolic derangements associated with obesity. Methods: We performed a case-control study in insulin-sensitive obese (ISO) and insulin-resistant obese (IRO) subjects (n = 12) and age-matched lean controls (n = 8) and measured serotonin transporter (SERT) binding in the whole...

...₀), homeostatic model assessment of insulin secretion (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) significantly improved compared to baseline. TT was the best predictor for FI. Percent change (Δ) of TT significantly correlated with ΔCholesterol, ΔWeight and ΔBMI. Compared to non-HG...

...Nicoleta C. Olarescu; Ansgar Heck; Kristin Godang; Thor Ueland; Jens Bollerslev Background/Aims: Adipose tissue (AT) distribution is closely related to metabolic disease risk. Growth hormone (GH) reduces visceral and total body fat mass and induces whole-body insulin resistance. Our aim...

... and secretion, but central prolactin effects on glucose homeostasis have not been examined. Here, we determined that chronic central infusion of prolactin modulates insulin resistance and β-cell function and mass in 90% of pancreatectomized diabetic male rats. Methods: Diabetic rats were divided into three...

... Matsuda index of insulin sensitivity (p = 0.039) confirmed insulin resistance in these patients. Conclusion: A potential long-term consequence of asymptomatic hypogonadism due to risperidone-induced hyperprolactinemia might cause a slight rise in bone resorption marker (CTx). On the other hand...

... risk in overt and subclinical Cushing’s syndrome. In Cushing’s syndrome, there is an increase of triglyceride and total cholesterol levels whereas HDL can be at variable levels. Overt and subclinical Cushing’s syndrome share many features with metabolic syndrome including insulin resistance, abnormal...

... directly by interfering with the insulin receptor signaling pathway or indirectly, through the stimulation of lipolysis and proteolysis and the consequent increase of fatty acids and amino acids, which contribute to the development of insulin resistance. Moreover, the peculiar distribution of adipose...

...Alia Munir; John Newell-Price Active Cushing’s syndrome is associated with insulin resistance induced by the high and prolonged circulating level of glucocorticoids. In endogenous Cushing’s syndrome the overall incidence of diabetes mellitus and insulin resistance is very likely to be under...